PMID: 6539729Jun 1, 1984Paper

Studies on the metabolic fate of sucrose esters in rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
T ShigeokaT Murata

Abstract

The metabolism in rats of sucrose esters of stearic acid and palmitic acid was studied in vivo and in vitro using esters labelled with 14C at the sucrose of fatty-acid moiety. In excretion studies, the ratio of expired radioactivity to absorbed radioactivity after oral administration of the sucrose esters labelled at the sucrose moiety was similar to that after the administration of [14C]sucrose. A similar correlation between the ester labelled at the fatty-acid moiety and the free [14C]fatty acid was also observed. No intact sucrose ester was detected in the urine. Studies in vitro using everted intestinal sacs showed that there was virtually no transport of 14C-labelled sucrose esters from the mucosal to the serosal solution through the intestinal tissues, and that the enzymes in the intestinal mucosa played a more important role in the hydrolysis of sucrose esters than did those in the digestive fluid. In studies of intestinal absorption through the mesenteric lymphatic system, during the 24 hr after ingestion 1.8% of the administered radioactivity was recovered in the lymph after dosing with [U-14C]sucrose monostearate whereas 20% was recovered in the lymph after dosing with sucrose [1-14C]monostearate. This difference in l...Continue Reading

References

Feb 1, 1979·Food and Cosmetics Toxicology·J W DanielD J Snodin

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Citations

May 10, 2011·Pharmaceutical Research·Phuong Ha-Lien TranBeom-Jin Lee
Aug 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G C DaherK W Miller
Jun 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P E NokerT Shigeoka
Dec 12, 2012·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Songa Ambedkar SunilKolapalli Venkata Ramana Murthy
Jul 22, 2014·Journal of Pharmaceutical Sciences·Lóránd KissMária A Deli
May 12, 2012·International Journal of Pharmaceutics·Angéla Szűts, Piroska Szabó-Révész
Jul 28, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Tatiana Cucu, Bruno De Meulenaer
Mar 1, 1992·Journal of Pharmaceutical Sciences·P PouillartP Villa
Jan 1, 1997·Journal of Neural Transmission·P DavidssonK Blennow

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