PMID: 4902891Jan 1, 1970Paper

Studies on the migratory behavior of melanocytes in guinea pig skin

The Journal of Experimental Medicine
R E Billingham, W K SILVERS

Abstract

Pigment spread is the natural or experimentally procured (through grafting) progressive encroachment of pigmentation from black or red skin areas into juxtaposed white skin areas, or from black skin areas into red skin areas in spotted guinea pigs and other mammals. So far as spread from black into white skin is concerned, it had previously been shown that migration of epidermal melanocytes into skin lacking homologues of these cells was responsible. However, since red skin already has its own complement of phenotypically "red" melanocytes, the intriguing possibility remained that when black pigment encroaches upon red, rather than melanocyte migration being responsible, phaeomelanin (red)-producing melanocytes are transformed into eumelanin (black)-producing cells by some kind of serially transmissible factor derived from contiguous eumelanotic melanocytes. By utilizing two isogenic strains (Nos. 2 and 13) of spotted guinea pigs and their F(1) hybrids, the mechanism underlying the spread of pigment from black into red skin has been analyzed, employing cellular transplantation antigens as melanocyte "markers." The findings demonstrate unequivocally that a physical migration of pigment cells is responsible. By comparing the exte...Continue Reading

Citations

Nov 1, 1977·The Journal of Dermatologic Surgery and Oncology·V J SelmanowitzE Wenk
Dec 1, 1978·The Journal of Dermatologic Surgery and Oncology·R Falabella
Jan 1, 1985·Cancer Metastasis Reviews·P B Armstrong
Oct 15, 2003·Transplantation·Clyde Barker
Mar 1, 1976·The Journal of Dermatologic Surgery·P Lobuono, H Shatin
Feb 1, 1984·The Journal of Dermatologic Surgery and Oncology·R Falabella
Dec 1, 2008·Expert Review of Dermatology·Graeme Walker, Neil Box
Feb 1, 1986·The Journal of Dermatologic Surgery and Oncology·R Falabella
Oct 28, 1976·Human Genetics·B K Davis, L D Verdol

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