PMID: 41594Dec 3, 1979

Studies on the mobilization of iron from ferritin by isolated rat liver mitochondria

Biochimica Et Biophysica Acta
R J Ulvik, I Romslo

Abstract

Rat liver mitochondria and rat liver mitoplasts mobilize iron from ferritin by a mechanism which depends on a respiratory substrate (preferentially succinate), a small molecular weight electron mediator (FMN, phenazine methosulphate or methylene blue) and (near) anaerobic conditions. The release process under optimized conditions (approx. 50 mumol/1 FMN, 1 mmol/l succinate, 0.35 mmol/1 Fe(III) (as ferritin iron), 37 degrees C and pH 7.40) amounts to 0.9--1.2 nmol iron/mg protein per min. The results suggest that ferritin might function as an intermediate in the cytosolic transport of iron to the mitochondria.

Citations

Jun 1, 1983·Journal of Bioenergetics and Biomembranes·R J Ulvik
Feb 1, 1987·Bulletin of Environmental Contamination and Toxicology·Z A Al-BayatiW A Al-Turk
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Related Concepts

Metazoa
Antimycin A1
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Isoferritin
Hydrogen-Ion Concentration
Iron
Mitochondria, Liver
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