PMID: 6168248Jan 1, 1981Paper

Studies on the mode of action of single-stranded polynucleotides which are antiviral against encephalomyocarditis virus infection of mice

Archives of Virology
N Stebbing

Abstract

Poly(dI) and poly(dC) administered separately or sequentially show no antiviral effects against EMC virus infection of mice, whereas poly(rI) and poly(rC) are antiviral in such treatment regimens without evidence of interferon induction. The antiviral effects of poly(rI) and poly(rC) appear to depend on single-strandedness because their antiviral effects are decreased by annealing to poly(dC) and poly(dI) respectively. This decrease in antiviral effect would not seem to be due to an adverse effect of polydeoxyribonucleotides on EMC virus infection because the polydeoxyribonucleotides have no effect on the antiviral activity of another single-stranded RNA, E. coli tRNA.

References

Sep 19, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·N StebbingM A Eaton
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E De ClercqB Witkop
Jul 1, 1978·The Journal of General Virology·E De ClercqM N Thang
Jan 1, 1977·The Journal of General Virology·N StebbingI J Lindley
Mar 4, 1977·Annals of the New York Academy of Sciences·N StebbingN H Carey
Jun 1, 1974·The Journal of General Virology·D W HutchinsonM A Eaton
May 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·C Colby, M J Chamberlin
Sep 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·S BaronR Naylor

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Citations

Jul 1, 1993·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·E FoniM Spinaci

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