PMID: 6403856Apr 1, 1983Paper

Studies on the mutagenic activity of ascorbic acid in vitro and in vivo

Mutation Research
E P NorkusA H Conney

Abstract

In vitro data are presented to show that ascorbic acid does not have intrinsic mutagenicity towards strain TA100 of S. typhimurium if deionized water is used to prepare the incubation medium. The addition of Cu2+ ions to the bacterial medium that contains ascorbic acid, or the use of tap water and ascorbic acid alone, causes a mutagenic and cytotoxic response that is blocked by EDTA. Additional in vitro data demonstrate that hydrogen peroxide is mutagenic to S. typhimurium strain TA100 and it is suggested that ascorbic acid may be mutagenic and cytotoxic through the generation of hydrogen peroxide. In vivo studies using a sensitive intrahepatic host-mediated mutagenicity assay indicate that ascorbic acid is not genotoxic in guinea pigs even when the dietary intake of vitamin C is above the level required for tissue saturation (5000 mg/kg body weight/day).

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Aug 1, 1976·Archives of Biochemistry and Biophysics·F J Yost, I Fridovich
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Citations

Jan 1, 1994·Teratogenesis, Carcinogenesis, and Mutagenesis·P K Khan, S P Sinha
Mar 5, 1999·Biological Trace Element Research·I DovinováL Novotný
Mar 1, 1984·Mutation Research·R J Shamberger
Feb 1, 1992·Journal of Toxicology and Environmental Health·G Rivas-OlmedoE Madrigal-Bujaidar
Jun 14, 2008·Biomedical and Environmental Sciences : BES·P K Khan, S P Sinha
Jan 1, 1987·Annals of the New York Academy of Sciences·J M Rivers
Feb 20, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S C MitchellR L Smith
Apr 1, 1995·Journal of the American College of Nutrition·A Bendich, L Langseth
Oct 21, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Gerard P McGregor, Hans K Biesalski
Jan 1, 1990·Environmental and Molecular Mutagenesis·P E Hartman, D M Shankel

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