Studies on the novel alpha-glucosidase inhibitory activity and structure-activity relationships for andrographolide analogues

Bioorganic & Medicinal Chemistry Letters
Gui-Fu DaiHong-Min Liu

Abstract

A series of analogues of andrographolide were synthesized and evaluated as novel alpha-glucosidase inhibitors. Among them compound 23, 15-p-methoxylbenzylidene 14-deoxy-11,12-didehydroandrographolide, was a potent inhibitor against alpha-glucosidase whose IC(50) value was 16microM. The structure-activity relationships were also discussed.

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Citations

May 28, 2013·Archives of Pharmacal Research·Sakkasem KasemsukRungnapha Saeeng
Apr 5, 2011·Journal of Asian Natural Products Research·Xiu-Lan XinMei-Hua Yang
Feb 17, 2009·Journal of Asian Natural Products Research·Xiu-Lan XinQi-Peng Yuan
May 9, 2012·Natural Product Research·Deepika Singh, Prabir K Chaudhuri
May 19, 2010·International Journal of Molecular Sciences·Jun XuYuqiang Wang
Jul 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ting ShenJae Youl Cho
Sep 9, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·N S Hari Narayana MoorthyPedro A Fernandes
Feb 15, 2012·Expert Opinion on Therapeutic Patents·Chantana Aromdee
Aug 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad Tayyab AkhtarKhozirah Shaari
Jun 6, 2008·Bioorganic & Medicinal Chemistry Letters·Hwangseo ParkKeun Kim
May 16, 2008·Organic & Biomolecular Chemistry·Marion DavoustJean-François Brière
Apr 5, 2007·Organic & Biomolecular Chemistry·Hai-Wei XuHong-Min Liu
Feb 4, 2011·Archiv der Pharmazie·Xuesen HuLin Ma
Jul 28, 2021·European Journal of Medicinal Chemistry·Hang ZhangHaiwei Xu

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