Studies on the post-ictal rise in seizure threshold

European Journal of Pharmacology
D J NuttA R Green

Abstract

Seizure thresholds were determined by timed infusion of a convulsant drug. Following an electroconvulsive shock (ECS) rats exhibited a raised seizure threshold to infusion of the GABA antagonist drugs, pentylenetetrazol, bicuculline and isopropyl-bicyclophosphate, but not to the glycine antagonist strychnine or the 5-HT agonist, quipazine. The increase in threshold was seen following a bicuculline-induced seizure and 30 min following the last of a course of ECS given once daily for 10 days. The rise in seizure threshold still occurred when animals were pretreated with alpha-methyl-p-tyrosine (200 mg . kg-1), p-chlorophenylalanine (200 mg . kg-2), naloxone (1 mg . kg-1) or indomethacin (20 mg . kg-1). Diazepam (2 mg . kg-1), flurazepam (10 mg . kg-1) and sodium valproate (400 mg . kg-1) elevated basal seizure threshold and a further rise followed the ECS. Phenytoin (40 mg . kg-1) and carbamazepine (40 mg . kg-1) had no effect on basal seizure threshold or the ECS-induce rise. (¿Propranolol (20 mg . kg-1) did not affect basal seizure threshold but prevented the ECS-induced increase. The rise in seizure threshold following a convulsion may be an important adaptive mechanism which could be related to the reported increase in specif...Continue Reading

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Citations

Jan 1, 1990·Psychopharmacology·A R GreenA J Cross
Sep 3, 1984·European Journal of Pharmacology·U TackeJ Tuomisto
Jan 1, 1987·Pharmacology, Biochemistry, and Behavior·C A Gramlich, J S Stripling
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Aug 14, 2010·Epilepsy & Behavior : E&B·Wolfgang Löscher, Rüdiger Köhling
Jan 1, 1986·Annals of the New York Academy of Sciences·B Lerer, B Shapira
Apr 1, 2016·Epilepsia·Victor FerastraoaruSheryl R Haut
Jan 1, 1988·British Journal of Pharmacology·R G Lister, D J Nutt
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Jan 1, 1985·Annals of the New York Academy of Sciences·G Zetler
Jan 1, 1986·Annals of the New York Academy of Sciences·J W HoladayR J Hitzemann
Jan 1, 1986·Annals of the New York Academy of Sciences·A R Green
Jun 1, 1986·Journal of Neurochemistry·M E AppleyardA D Smith
Sep 1, 1984·Acta Pharmacologica Et Toxicologica·U Tacke, C Braestrup

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