PMID: 6965701Jan 1, 1980Paper

Studies on the presence of vasopressin, oxytocin and vasotocin in the pineal gland, subcommissural organ and fetal pituitary gland: failure to demonstrate vasotocin in mammals

The Journal of Endocrinology
J DogteromD F Swaab

Abstract

The demonstration of vasotocin in the mammalian pineal gland, subcommissural organ and fetal pituitary gland by bioassay has led to hypotheses regarding the function of this hormone in various reproductive processes. Preliminary examinations of the pineal gland and subcommissural organ with a specific radioimmunoassay failed to show vasotocin immunoreactivity. The presence of vasotocin, vasopressin and oxytocin in the pineal gland, subcommissural organ and fetal neurohypophysis was therefore investigated, using three specific radioimmunoassays. Frog and chicken pituitary glands were used to validate the vasotocin radioimmunoassay. Direct measurements in diluted homogenates of pituitary glands from frogs, chickens, mid-term fetal sheep and near-term fetal seals revealed the presence of vasotocin only in the frog and chicken pituitary glands, while vasopressin and oxytocin were found in the two fetal pituitary homogenates. Vasopressin and ocytocin were measured in homogenates of rat and bovine pineal glands and in preparations of the subcommissural organ of rats and rabbits after extraction with Vycor glass powder, but no specific vasotocin immunoreactivity was observed. These results indicate a discrepancy between the reported b...Continue Reading

Citations

Apr 24, 2009·Cell and Tissue Research·S SchönigerF Nürnberger
Dec 1, 1980·Pharmacology, Biochemistry, and Behavior·A J KastinD H Coy
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·G Meisenberg, W H Simmons
Jan 1, 1982·Pharmacology & Therapeutics·D H Versteeg
Jan 1, 1983·Pharmacology & Therapeutics·G P KozlowskiE A Zimmerman
Jan 1, 1996·Neurochemistry International·M MøllerB Cozzi
Dec 1, 1993·Molecular and Cellular Endocrinology·S Lopes da SilvaJ P Burbach
Jul 1, 1989·Early Human Development·H P Oosterbaan, D F Swaab
May 1, 1985·The Journal of Clinical Investigation·M G ErvinD A Fisher
Sep 1, 1989·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·F M HelmerhorstR M Lequin
Oct 1, 1993·Journal of Pineal Research·J L Castillo-RomeroD Acuña-Castroviejo
Dec 1, 1983·British Journal of Obstetrics and Gynaecology·D F Swaab, H P Oosterbaan
Mar 1, 1983·British Journal of Obstetrics and Gynaecology·C F GoodfellowR M Buijs
Jan 1, 1989·Journal of Pineal Research·M M PrechelW H Simmons
Jan 1, 1984·Journal of Pineal Research·M M PrechelW H Simmons
Jan 1, 1988·Journal of Pineal Research·H P NotebornC A Salemink
May 2, 1998·The Journal of Obstetrics and Gynaecology Research·T IjuinY Nagata
Mar 10, 2001·Microscopy Research and Technique·F Nürnberger, S Schöniger

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