PMID: 3772204Sep 1, 1986Paper

Studies on the relationship between reproductive phenomena and thyroid function--dynamics of the concentrations of thyroid hormones in pregnancy, parturition and puerperium

Nihon Sanka Fujinka Gakkai zasshi
H NakayamaM Mochizuki

Abstract

Thyroid function during pregnancy, parturition and puerperium was studied by measuring the concentration of free thyroxine (f-T4), free triiodothyronine (f-T3) and reverse triiodothyronine (r-T3) in maternal and cord sera, and simultaneously metabolism of thyroid hormones in chorionic tissues was examined. Results obtained were as follows: In cases of normal pregnancy, maternal f-T4 and f-T3 levels tend to decrease during the course of pregnancy toward parturition. Pathological pregnancies such as intra uterine growth retardation (IUGR) and toxemia (H, h) showed a tendency for maternal f-T3 to decrease and for r-T3 to increase, compared to normal cases at the same gestational age. Maternal f-T3 levels were significantly higher and r-T3 were lower than those of cord sera. Inner monodeiodination activity was found in the placenta, and T4 incubated with chorionic tissue was mainly converted to r-T3. From these findings, it was suggested that the metabolic state of pregnant women would become hypometabolic during the course of pregnancy toward parturition. Higher r-T3 and lower f-T3 levels in pathological pregnant women indicated that T4 to r-T3 conversion might be more dominant than T4 to T3 because of the maternal intensified hyp...Continue Reading

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