Studies on the renal excretion of norepinephrine

The Journal of Clinical Investigation
H R OveryC A Chidsey

Abstract

Studies were carried out in anesthetized dogs to investigate the renal clearance of norepinephrine (NE) and to determine the origin of this amine in the urine. Infused radioactive NE was cleared from plasma at a rate averaging 63.8% of the glomerular filtration rate. NE was shown to be freely filterable, and evidence has been presented which suggests but does not prove that the amine is partially reabsorbed from the glomerular filtrate; metabolism of NE in the tubular fluid by catechol-o-methyl transferase has not been excluded. The clearance of this catecholamine was not affected by changes in urine pH or flow. Total chronic denervation of one kidney was shown to have no effect on the rate of excretion of endogenous NE. Therefore, the NE that is excreted in the urine would appear to be solely derived from the catecholamines in circulating blood.

References

May 1, 1961·The Journal of Surgical Research·T S HARRISON
Sep 27, 1962·The New England Journal of Medicine·C A CHIDSEYE BRAUNWALD
Mar 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A CHIDSEYE BRAUNWALD
Jan 1, 1963·Japanese Heart Journal·T TOMOMATSUY KONDO
Sep 1, 1963·Annals of Internal Medicine·D C HARRISONE BRAUNWALD
May 1, 1964·The American Journal of Medicine·I M WEINER, G H MUDGE
Sep 1, 1965·The American Journal of Medicine·C A CHIDSEYA G MORROW
Aug 1, 1962·Acta Physiologica Scandinavica·E SANNER, B WORTMAN
May 1, 1950·Proceedings of the Society for Experimental Biology and Medicine·G E SCHREINER

❮ Previous
Next ❯

Citations

May 27, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·K HempelA Heidland
Apr 30, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·K HempelA Heidland
Aug 1, 1973·European Journal of Clinical Pharmacology·G BufanoR Starcich
Sep 1, 1985·Pflügers Archiv : European journal of physiology·L LinkA Futterlieb
May 1, 1978·Canadian Anaesthetists' Society Journal·K BalasaraswathiR Pifarre
Mar 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·G P ReynoldsM Sandler
Dec 17, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·N D Vlachakis, A Niarchos
Mar 15, 1979·European Journal of Pharmacology·G FeuersteinY Gutman
Jul 1, 1970·Journal of Psychiatric Research·P V Cardon, F G Guggenheim
Jan 1, 1987·Journal of Psychosomatic Research·A Steptoe
Mar 4, 2000·Clinical and Experimental Pharmacology & Physiology·S YuasaH Matsuo
Jan 4, 1973·The New England Journal of Medicine·M D Esler, K J Goulston
Apr 1, 1973·Australian and New Zealand Journal of Medicine·M D Esler, P J Nestel
Oct 1, 1968·The Journal of Clinical Investigation·V DeQuattro, A Sjoerdsma
Sep 1, 1979·The Journal of Clinical Investigation·P SilvaA Besarab
Oct 19, 2011·Anesthesiology Research and Practice·Dominic Hegarty
Jan 1, 1976·Endocrine Research Communications·B FaucheuxJ Genest
Jan 1, 1981·Clinical and Experimental Hypertension : CHE·S GitlowI Roubein
Oct 1, 1973·The American Journal of Cardiology·M D Esler, P J Nestel
Sep 1, 1973·The American Journal of Medicine·V DeQuattro, Y Miura
Oct 31, 1975·The American Journal of Cardiology·S Julius, M Esler
Apr 10, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nuno Miguel PiresPatrício Soares-da-Silva
May 1, 1979·Journal of the American Geriatrics Society·K ItoK Kamata
Nov 1, 1970·Australasian Annals of Medicine·M Rosenbaum, A E Doyle
Oct 1, 1976·Archives internationales de physiologie et de biochimie·J Juchmès, V Bourdon
Feb 1, 1979·Archives internationales de physiologie et de biochimie·J JuchmèsA Brose
Aug 11, 1973·The Medical Journal of Australia·M D Esler, P J Nestel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.