Studies on the reproductive, cytological and biochemical toxicity of Ginkgo Biloba in Swiss albino mice

Journal of Ethnopharmacology
Abdulaziz A Al-YahyaS Qureshi

Abstract

Ginkgo biloba (an herbal product), used as a folkloric medicine in the treatment of dementia, was evaluated for its effects on reproductive, cytological and biochemical toxicity in male Swiss albino mice. The mice were treated with different doses (25, 50 and 100mg/kg/day) of the aqueous suspension of Ginkgo biloba for 90 days by oral gavage. The following parameters were evaluated: (1) reproductive organ weight; (2) motility and content of sperms; (3) spermatozoa morphology; (4) cytology of the testes chromosomes; (5) study on reproduction; (6) biochemical study on proteins, nucleic acids, malondialdehyde (MDA) and nonprotein sulfhydryl (NP-SH). The treatment caused significant changes in the weight of caudae epididymis, prostate, chromosomal aberrations, rate of pregnancy and pre-implantation loss. However, the percent motility, sperm count and morphology of spermatozoa were not affected. Our study on biochemical parameters showed depletion of nucleic acids, NP-SH and increase of MDA, which elucidated the role of free radical species in the induced changes in testis chromosomes and the reproductive function. The exact mechanism is not known, however, the activation of GABA, glycine and glutamate under the influence of Ginkgo ...Continue Reading

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Citations

Apr 30, 2010·Biological Trace Element Research·Fabrícia de Souza PredesHeidi Dolder
Jul 2, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Li LiSu Zeng
Dec 3, 2014·Toxicology·Kerstin BergDieter Schrenk
Dec 6, 2012·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Reda H Elmazoudy, Azza A Attia
Nov 2, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Egon KochJost Leuschner
Jan 6, 2017·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Nan MeiLei Guo
Sep 1, 2007·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Po-Chuen ChanPeter P Fu
May 5, 2009·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Peter P FuHongtao Yu

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