PMID: 7030527Jul 1, 1981Paper

Studies on the responses of plasma renin activity and aldosterone and cortisol levels to dopaminergic and opiate stimuli in man

Clinical Endocrinology
S L Lightman

Abstract

Evidence for a role of dopamine and endogenous opioids in the control of the secretion of renin and adrenal steroids was sought in man. The effects of L-dopa, L-dopa plus carbidopa, dopamine, domperidone and naloxone were studied on the renin and aldosterone responses to head-up tilt. L-dopa diminished the rise in renin following tilt and this effect of L-dopa was abolished by carbidopa. Aldosterone was not significantly affected by any of the compounds. Cortisol secretion was stimulated by carbidopa plus L-dopa more than L-dopa alone, and was also increased by both dopamine and naloxone. The significance of these findings is discussed.

References

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Citations

Jan 1, 1988·European Journal of Clinical Pharmacology·D WorthM Lee
Jan 14, 2000·Psychoneuroendocrinology·J HennigP Netter
Dec 1, 1983·Clinical Endocrinology·N FrisinaM Buemi
Sep 1, 1981·British Journal of Obstetrics and Gynaecology·S L LightmanS L Jeffcoate
Sep 1, 1991·Angiology·I SaitoT Sekihara
Jan 1, 1984·International Journal of Health Services : Planning, Administration, Evaluation·R E Zambrana, M Hurst

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