Studies on the role of HLA-DR in macrophage-T cell interactions

Tissue Antigens
S Bright, A J Munro

Abstract

The purpose of this paper is to illustrate the difficulties we have encountered in attempting to analyse the role of HLA-DR in the antigen-dependent co-operation between macrophages and T cells which leads to a T-cell proliferative response. We have adopted the two most commonly used approaches; attempted inhibition by anti-HLA-DR antisera and study of co-operation between cells of unrelated individuals, and have found both methods unsatisfactory. With the first method we found that anti-HLA antisera could inhibit proliferative responses in a non-specific manner. Both anti-HLA-A, B and anti-HLA-DR antisera could inhibit and this inhibition was largely Fc-dependent. Using pepsin-digested antisera we have no evidence for a unique role for HLA-DR in these proliferative responses. The second method, study of co-operation between cells of unrelated individuals, proved extremely difficult to analyse because of the background allogeneic reaction. Whether cells of two individuals appeared to co-operate to give an antigen-specific response depended on the number of cells used and the calculations applied to the data. However, it was clearly possible to demonstrate co-operation between DR different individuals.

References

Jan 1, 1977·Immunological Reviews·D W ThomasE M Shevach
Sep 1, 1978·British Medical Bulletin·J G Bodmer
Sep 1, 1978·British Medical Bulletin·A Munro, H Waldmann
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R S GehaE J Yunis
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Jan 1, 1980·Tissue Antigens·M Jonker, L de Rooy-Doyer

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Citations

Nov 1, 1988·Molecular Immunology·L TrónS Damjanovich
Aug 1, 1991·Human Immunology·H NiizekiT Nishikawa
Oct 1, 1983·Clinics in Dermatology·A R Ahmed
Nov 1, 1988·Quarterly Reviews of Biophysics·J MatkóS Damjanovich
Aug 1, 1992·American Journal of Reproductive Immunology : AJRI·M Kurpisz, N Fernandez
Aug 1, 1992·American Journal of Reproductive Immunology : AJRI·N S RoteT W Lyden
Oct 1, 1987·Immunology Letters·L TrónS Damjanovich
Sep 1, 1984·Tissue Antigens·J Neppert, C Mueller-Eckhardt
Jan 1, 1982·Immunological Reviews·E ThorsbyH Nousiainen

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