PMID: 2484363Sep 1, 1988Paper

Studies on the role of iron in the reversal of cadmium toxicity in chicks

Biological Trace Element Research
T L Blalock, C H Hill

Abstract

Studies were conducted to determine the effect of dietary iron (Fe) levels ranging from a deficiency to an excess on the toxicity of cadmium (Cd) in chicks. In Fe-deficient animals, cadmium was found to be more toxic than in Fe supplemented animals as measured by growth. The liver Cd burdens were increased significantly in the presence of dietary Fe supplementation, and there was a significant Cd-Fe interaction in the Cd concentration of the kidney, indicating that iron deficiency increased the concentration of Cd in the kidneys of those chicks receiving this element. Cd tended to reduce the Fe concentration in both the liver and kidney. The absorption of Cd as measured by the amount of 109Cd that disappeared from an isolated duodenal segment in one h was not affected by the Fe content of the diet, but the amount of isotope appearing in the liver compared to the amount present in the blood was increased in the Fe supplemented chicks. Separation of the Cd binding ligands by column chromatography revealed that more of the Cd in the liver, but not the kidney, was associated with ligands which eluted in a column volume that contained metallothionein in those chicks receiving Fe than in the livers from Fe deficient animals. The inve...Continue Reading

References

May 1, 1973·Archives of Environmental Health·Y ItokawaS Tanaka
Oct 1, 1971·The Journal of Nutrition·M R FoxC E Weeks
Jul 1, 1963·The Journal of Nutrition·C H HILLC W BARBER
Dec 1, 1987·Biological Trace Element Research·T L Blalock, C H Hill

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Citations

Jun 20, 2007·Nihon eiseigaku zasshi. Japanese journal of hygiene·Hyogo Horiguchi
Jul 11, 2009·Angewandte Chemie·Katrin Marie DrillerMatthias Beller
Jan 7, 2021·Biological Trace Element Research·Indrajit Kar, Amlan Kumar Patra

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