PMID: 2484356Sep 1, 1988Paper

Studies on the role of iron in zinc toxicity in chicks

Biological Trace Element Research
T L Blalock, C H Hill

Abstract

The interaction of dietary iron and zinc was studied in chicks. Zinc was found to be more toxic in iron-deficient animals than iron-supplemented animals as measured by hemoglobin concentrations and growth. Analyses of the kidney and liver for iron and zinc were carried out. As the level of iron was increased from 0-1000 ppm supplementation, the concentration of liver zinc increased. The organ levels of iron were decreased as the dietary zinc levels were increased from 0-5000 ppm. Radioisotope studies using 65Zn revealed that the iron content of the diet did not affect absorption of zinc. Administration of the isotope, either in an intestinal segment or intravenously, resulted in more zinc being taken up by the liver in the iron supplemented animals. This was especially noted when the ratio of the isotope in liver to that in the blood was compared. Gel chromatography of kidney and liver homogenates revealed that iron deficiency resulted in less zinc being eluted in a volume characteristic of metallothionein compared to homogenates of organs from iron supplemented animals. The results indicate that iron-supplemented animals have a greater capacity for sequestering zinc on metallothionein than do iron-deficient animals. Conversely...Continue Reading

References

Jul 1, 1976·Journal of Toxicology and Environmental Health·J K Piotrowski, J A Szymańska
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Citations

Jan 6, 2001·Journal of the Royal Army Medical Corps·C MacFarlaneC A Benn
Apr 14, 2004·American Journal of Veterinary Research·Mary M ChristopherJeffrey M Levengood
Jan 1, 1990·Acta Oncologica·H T MouridsenT Skovsgård
Jan 7, 2019·Biological Trace Element Research·Gretchen Myers Hill, Marcia Carlson Shannon

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