PMID: 14406413Nov 1, 1959Paper

Studies on the role of N-acetylaspartic acid in mammalian brain

The Journal of General Physiology
K B JACOBSON

Abstract

N-Acetylaspartic acid (NAA) occurs at relatively high concentrations exclusively in the mammalian and avian brain and undergoes rapid rise in level soon after birth (Tallan, 1957). The amount of NAA in brains of mentally abnormal human beings and of young human beings was measured. The route by which NAA is synthesized was shown to involve a direct acetylation of aspartic acid. The degradative activity of the brain toward NAA is slight. Some experiments indicate that NAA in the brain is a physiologically and metabolically active compound.

Citations

Mar 26, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·M MiyakeY Kakimoto
Aug 15, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·E A KvittingenE Jellum
Aug 1, 1995·Progress in Neurobiology·G Tsai, J T Coyle
Dec 18, 1978·Biochimica Et Biophysica Acta·M MiyakeM Sorimachi
Jun 20, 2001·Journal of the Neurological Sciences·K KamadaJ Vieth
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J M Ffrench-MullenD O Carpenter
Sep 1, 1965·Journal of Neurochemistry·J C McIntosh, J R Cooper
Nov 1, 1966·Journal of Neurochemistry·F MarcucciS Garattini
Mar 1, 1969·Journal of Neurochemistry·R Lim, B W Agranoff
Sep 1, 1971·Journal of Neurochemistry·H Weil-Malherbe, J Gordon
Dec 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·M UzanC Kuday
Sep 1, 1972·Journal of Neurochemistry·J V Nadler, J R Cooper
Oct 1, 1973·Journal of Neurochemistry·K L Reichelt, E Kvamme
Sep 1, 1966·Journal of Neurochemistry·R M O'Neal, R E Koeppe
Sep 1, 1966·Journal of Neurochemistry·M C Fleming, O H Lowry
Mar 1, 1988·Diabetes/metabolism Reviews·B K Siesjö
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·D L Birken, W H Oldendorf
Jun 1, 1966·Canadian Journal of Biochemistry·L Berlinguet, M Laliberté
May 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T EbisuA A Maudsley
Jul 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T DalkaraM A Moskowitz
Dec 1, 1992·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·G BartaliniA Fois
Aug 1, 1965·Journal of Neurochemistry·H C BuniatianG V Aprikian
Jan 1, 1993·Journal of Inherited Metabolic Disease·R MatalonK Michals
Jan 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H BruhnR Sauter
Jul 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmR Sauter
Feb 1, 1988·American Journal of Medical Genetics·R MatalonJ Casanova
Jan 1, 1987·Journal of Inherited Metabolic Disease·L HagenfeldtN Venizelos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.