PMID: 6408491Mar 1, 1983Paper

Studies on the role of serotonin in different regions of the rat central nervous system on pentylenetetrazol-induced seizures and the effect of di-n-propylacetate

Naunyn-Schmiedeberg's Archives of Pharmacology
M LazarovaR Samanin

Abstract

5,7-Dihydroxytryptamine (5,7-DHT) injections which caused selective depletion of serotonin in the forebrain enhanced the seizures caused by pentylenetetrazol (PTZ 90 mg/kg s.c.) in rats. No effect was observed in rats with 5,7-DHT-induced depletion of spinal serotonin or treated with metergoline (1 mg/kg i.p.) or methysergide (10 mg/kg i.p.). The various procedures aimed at decreasing serotonin transmission did not significantly modify the effect of di-n-propylacetate (DPA) on tonic seizures and mortality caused by PTZ but significantly reduced the DPA-induced increase in the latency to the first convulsion. More animals with clonic seizures were seen in the DPA-treated group which had been subjected to selective depletion of spinal serotonin or treated with methysergide than in DPA-treated controls. Combined treatment with d-fenfluramine (1.25 mg/kg i.p.) and DPA (75 mg/kg i.p.), doses which by themselves had no significant effect, reduced tonic seizures and mortality caused by PTZ. The results show that a diffuse deficit in forebrain serotonin enhances PTZ-induced seizures. Serotonin does not play an important role in the effect of DPA against PTZ-DPA on clonic convulsions. Agents increasing serotonin transmission may enhance...Continue Reading

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Citations

Mar 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·S RomandiniR Samanin
Jan 11, 2001·Pharmacology & Therapeutics·S J Bonasera, L H Tecott
Aug 1, 1997·Nature Genetics·T J BrennanL H Tecott
Dec 24, 2005·Epilepsy Currents·Harry T Chugani, Diane C Chugani
Mar 1, 1985·The Journal of Pharmacy and Pharmacology·P S WhittonM Bulat
Feb 9, 2017·Canadian Journal of Physiology and Pharmacology·Abdelaziz M HusseinEl-Hussainy M A El-Hussainy
Oct 19, 2010·Journal of Veterinary Pharmacology and Therapeutics·H K Dimaio KnychS D Stanley
Dec 1, 1985·Environmental Health Perspectives·P Neta, R E Huie
Mar 23, 2017·Frontiers in Cellular Neuroscience·Anders V PetersenJean-François Perrier
Dec 14, 2018·The International Journal of Neuroscience·Mehmet TaskiranErdal Agar
Nov 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·D LouwJ Girvin
Sep 3, 2020·CNS Drugs·Ganna BalaguraAlberto Verrotti

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