PMID: 6113533Jul 1, 1981Paper

Studies on the role of the liver and splanchnic tissues in the production of carbohydrate intolerance in uremia

Metabolism: Clinical and Experimental
J A DelmezJ Blondin

Abstract

The potential contribution of the splanchnic tissues to the carbohydrate intolerance of uremia was studied in fasted, partially nephrectomized rats. The livers of sham operated (C) and partially nephrectomized (Nx) rats were perfused with physiologic concentrations of potential gluconeogenic substrates using a nonrecirculating perfusion apparatus. Glucose release was slightly greater in the livers of Nx rats as compared to C rats. The portal vein concentrations of the potential gluconeogenic precursors were not different in the two groups. Moreover, there were no differences in the net hepatic extraction of alanine, glutamine or glutamate between the two groups of rats. There was also no difference in the production of glucose from U14C alanine. The livers of Nx rats, however, demonstrated less net extraction of lactate and released greater concentrations of betahydroxybutyrate. The increased release of glucose by livers of Nx rats may be at least partially due to their greater hepatic glycogen content.

References

Jan 1, 1975·The American Journal of Physiology·P J Blackshear, Alberti KGMM
Jul 1, 1977·The Journal of Clinical Investigation·V Soman, P Felig
Dec 1, 1978·Metabolism: Clinical and Experimental·R A DeFronzo
Feb 1, 1975·Clinical Biochemistry·A MannanD S Silverberg
Mar 1, 1976·The Journal of Clinical Investigation·R S SherwinP Felig
Jan 1, 1968·Advances in Enzyme Regulation·H A Krebs
Dec 1, 1974·The American Journal of Physiology·H R HarterS Klahr
Sep 1, 1973·Medicine·R A DeFronzoW G Walker
May 1, 1973·European Journal of Clinical Investigation·K P MaierW Gerok
Aug 1, 1974·Analytical Biochemistry·J V Passonneau, V R Lauderdale
Dec 1, 1971·The Journal of Clinical Investigation·P Felig, J Wahren
Feb 1, 1970·Metabolism: Clinical and Experimental·N A Samaan, R M Freeman
Sep 1, 1970·The American Journal of Physiology·W W Lacy
Apr 1, 1971·The Journal of Clinical Investigation·E B MarlissG F Cahill
Jan 1, 1968·Annals of Internal Medicine·E S HortonH E Lebovitz
Jun 15, 1968·Experientia·R Dzúrik, E Brixová
May 1, 1965·Analytical Biochemistry·E Van Handel
Nov 1, 1966·The Journal of Clinical Investigation·C L HampersJ P Merrill
Feb 1, 1967·The Journal of Clinical Investigation·S W ShankelN S Bricker
Jun 1, 1967·The Journal of Clinical Investigation·M J Chamberlain, L Stimmler
Jun 1, 1967·Annals of Internal Medicine·J M Cerletty, N H Engbring
May 1, 1960·The American Journal of Physiology·N B CUMMINGS, S M ZOTTU

❮ Previous
Next ❯

Citations

Nov 15, 1987·Analytical Biochemistry·A W WolkoffT Goeser
Jan 1, 1987·Diabetes/metabolism Reviews·E A Newsholme, J C Stanley
Jan 1, 1987·Diabetes/metabolism Reviews·L Hue

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.