Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors

Bioorganic & Medicinal Chemistry Letters
Chen ChenMingzhu Zhang

Abstract

Derivatives of milnacipran were synthesized and studied as monoamine transporter inhibitors. Potent analogs were discovered at NET (9k) and at both NET and SERT (9s and 9u). A pharmacophore model was established based on the conformational analysis of milnacipran in aqueous solution using NMR techniques and was consistent with the SAR results.

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Citations

Jun 27, 2009·Chemical Communications : Chem Comm·Jacob AndersenKristian Strømgaard
Sep 16, 2014·Catalysis Science & Technology·Hans RenataFrances H Arnold
Apr 15, 2021·Nature Communications·Shabareesh PidathalaAravind Penmatsa
May 1, 2008·Bioorganic & Medicinal Chemistry Letters·Junko TamiyaChen Chen

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