STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS : X. ANTIBODIES INDUCING IMMEDIATE-TYPE SKIN REACTIONS.

The Journal of Experimental Medicine
M W Chase

Abstract

Evidence is presented to show that guinea pigs actively sensitized to simple chemical compounds form serum antibodies capable of sensitizing the skin of normal guinea pigs. Skin sites prepared as for the Prausnitz-Küstner test develop immediate-type ("evanescent") reactions with erythema and edema, upon subsequent injection of the corresponding simple compounds or protein conjugates thereof, and give effects resembling transferred reaginic reactions as seen in human beings. The antibodies were obtainable after sensitization by acyl chlorides, acid anhydrides, and also substances of lesser reactivity, picryl chloride and 2:4 dinitrochlorobenzene, which are human allergens. Observations are reported on the specificity of the antibodies and on various details of the reaction. Like effects result when antiprotein immune sera and their corresponding antigens are employed for the test, making it highly probable that the antibodies secured after sensitization to drugs result from immunization by conjugates formed in vivo. The sera obtained after sensitization with simple chemical compounds readily confer passive anaphylaxis, and their capacity for sensitizing the skin declines gradually with progressive heating. It was observed that f...Continue Reading

References

Jan 31, 1932·The Journal of Experimental Medicine·J Freund
Sep 30, 1936·The Journal of Experimental Medicine·K Landsteiner, J Jacobs
Oct 31, 1938·The Journal of Experimental Medicine·R J Parsons, P D McMaster

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Citations

Mar 1, 1964·The Journal of Allergy·S O FREEDMAN
Jan 29, 2002·International Immunopharmacology·Xing Dong ZhangDaniel M Lewis
Jan 2, 1965·Nature·S BEN-EFRAIM, B CINADER
May 27, 1948·The New England Journal of Medicine·W S BURRAGE
Dec 13, 1951·The New England Journal of Medicine·E A CARR
Oct 1, 1982·Journal of Toxicology and Environmental Health·J R Cushman, J C Street
Mar 1, 1948·The Journal of Experimental Medicine·J R McCARTER, E B BEVILACQUA
Nov 13, 2015·Contact Dermatitis·Helen SingletonRebecca J Dearman
Mar 1, 1956·The Journal of Pediatrics·K L BURDON
Sep 1, 1955·The Journal of Allergy·H RASMUSSEN
May 1, 1957·The Journal of Allergy·R L MAYER
Apr 1, 1989·British Journal of Industrial Medicine·K M Venables

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.