Studies on the separation of 99mTc from large excess of molybdenum

Nuclear Medicine Review. Central & Eastern Europe
Wioletta WojdowskaRenata Mikołajczak

Abstract

Due to aging and unexpected prolonged shutdown of nuclear reactors producing ⁹⁹Mo for ⁹⁹Mo/ 99mTc generators it was necessary to explore the alternative methods of technetium-99m production. The first choice were the accelerators. Three years ago IAEA (International Atomic Energy Agency) initiated the Coordinated Research Project "Accelerator-based Alternatives to Non-HEU production of Mo-99 /Tc-99m" aimed at direct production of 99mTc in proton accelerators using the ¹⁰⁰Mo(p,2n)99mTc reaction. POLATOM is participating in this enterprise together with the Heavy Ion Laboratory of Warsaw University and the Institute of Nuclear Chemistry and Technology. ⁹⁹Mo/99mTc solutions and pure 99mTc used for generators production or milked from ready to use generators were used in experiments. Commercial chromatographic and laboratory-prepared columns were used for separation. The peristaltic pumps were used for solutions delivery onto the columns. Radioactivity of eluted ⁹⁹Mo and 99mTc was measured using high resolution gamma spectrometry or ionisation chamber in case of high radioactivity. For separation, three different chromatographic methods were used, one based on ion exchange and two on extraction. Synthetic mixtures simulating the re...Continue Reading

Citations

May 6, 2016·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·D W PawlakR Mikołajczak

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