PMID: 6730204Mar 1, 1984

Studies on the sequential development and pathogenesis of citrinin mycotoxicosis in turkeys and ducklings

Veterinary Pathology
N A MehdiJ Tuite

Abstract

The toxic effects of citrinin in turkeys and ducklings was studied in four trials. Citrinin dissolved in dimethyl sulfoxide-70% ethanol solution (3:1, volume/volume) was administered by gavage to male turkey poults and male white Pekin ducklings. When seven-day-old ducklings were given doses of citrinin between 30 to 110 mg/kg body weight, most of the treated ducklings which died (49/80) did so within four to 12 hours. Blood samples were collected sequentially at 3, 6, 12, and 24 hours after administration from seven-day-old ducklings given the single lethal dose (LD50). The alterations included hyperkalemia (P less than or equal to 0.01) and metabolic acidosis characterized by reduced blood pH (P less than or equal to 0.01) and base excess (P less than or equal to 0.01). Fourteen-day-old turkeys and ducklings given 56 or 57 mg/kg, respectively, were killed at 1, 3, 6, 12, 24, 48, and 72 hours after treatment. The principal alteration in both species was nephrosis that was more severe in turkeys than in ducklings. Tubular necrosis was the dominant lesion at three to 72 hours in turkeys and at six to 24 hours in ducklings. Hepatic and lymphoid lesions occurred in both turkeys and ducklings treated with citrinin.

References

Mar 1, 1979·Toxicology·R D PhillipsA W Hayes
Feb 1, 1977·Food and Cosmetics Toxicology·A W HayesB G Moore
Jan 1, 1978·Toxicon : Official Journal of the International Society on Toxinology·R D Phillips, A W Hayes
Oct 1, 1978·Food and Cosmetics Toxicology·W H JordanG A Sansing
Oct 1, 1978·Food and Cosmetics Toxicology·W H JordanG A Sansing
Dec 1, 1981·Food and Cosmetics Toxicology·N A MehdiJ Tuite
May 1, 1980·Toxicology Letters·E E CreppyG Dirheimer
Jan 1, 1983·Avian Pathology : Journal of the W.V.P.A·N A MehdiJ Tuite

Citations

May 1, 1986·Veterinary Pathology·C HanikaJ Tuite
Apr 1, 1989·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·G E RottinghausT P Brown
Dec 30, 2006·Molecular Nutrition & Food Research·Annie Pfohl-Leszkowicz, Richard A Manderville

Related Concepts

Benzopyrans
Citrinin
Ducks
Kidney Diseases
Liver Dysfunction
Status Lymphaticus
Mycotoxins
Necrosis
Poultry Diseases
Meleagridinae

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