PMID: 6972275Feb 1, 1981Paper

Studies on the sub-banding of creatine kinase MM and the "CK conversion factor"

Clinical Biochemistry
H FalterW Whiston

Abstract

In serum, the M subunit of creatine kinase (CK) isoenzymes, MM and MB, is modified by a heat labile factor. As a result of the modification three sub-bands of MM and two of MB can be demonstrated by agarose electrophoresis. Normal sera contain MM1 as the dominant sub-band with lesser amounts of MM2 and MM3. Following tissue damage the MM sub-band distribution changes as a result of the increased release of MM, which occurs as MM3. Immediately after coronary bypass surgery MM3 is the dominant sub-band to be replaced by MM2 and in turn by MM1. The factor responsible for the modification of the M subunit, the "CK conversion factor" has been partially purified and its molecular weight determined.

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Citations

Jun 16, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·N HeinbokelH W Goedde
May 9, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·B G Guslits, H K Jacobs
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May 30, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·R A WeversJ B Soons
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Dec 31, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·A A van LandeghemT Antonissen-Zijda
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Aug 1, 1982·Clinical Biochemistry·H FalterW Whiston

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