Studies on the time course of the effects of the probiotic yeast Saccharomyces boulardii on electrolyte transport in pig jejunum

Digestive Diseases and Sciences
B SchroederG Breves

Abstract

Orally administered Saccharomyces boulardii (synonym Saccharomyces cerevisiae Hansen CBS 5926) has already been shown to affect relevant functions of the mucosa in pig jejunum such as lowering the secretory response to theophylline or stimulating sodium/glucose cotransport, but knowledge of time-dependent relationship is minimal. In this study we examined the effects of S. boulardii on sodium (Na+) and chloride (Cl-) transport in pig jejunum under nonstimulated (basal) and stimulated (secretory) conditions. For this purpose the conventional Ussing chamber method was used for measuring electrical parameters (short circuit currents, Isc; tissue conductances, G(T)) and electrolyte transport of isolated intact jejunal epithelia in the absence and presence of the secretagogue theophylline (10 mM, serosal side). Time profiles of the mucosa response were assessed by treating animals perorally with S. boulardii for 0 (control), 3, 8, and 16 days. Intestinal tissues were obtained from growing pigs in the weight range between 25 and 40 kg. All animals were fed twice daily and received 1.0-1.6 kg/day of a standard diet avoiding probiotics as food additives. After a 9- to 10-day adaptation period the diets for treated animals were suppleme...Continue Reading

Citations

Oct 22, 2005·Digestive Diseases and Sciences·Philippe GirardJean-Marie Gillardin
Dec 17, 2010·British Poultry Science·M AfsharmaneshF G Silversides
May 12, 2010·World Journal of Gastroenterology : WJG·Lynne V McFarland
Aug 30, 2013·Canadian Journal of Physiology and Pharmacology·Kevin W Lomasney, Niall P Hyland
Feb 18, 2011·Journal of the Science of Food and Agriculture·Carme Plumed-Ferrer, Atte von Wright
Apr 29, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Marcella Lobato D ConsoliMaria Isabel T D Correia
Sep 10, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Saskia ThomasDaniel C Baumgart
May 31, 2019·World Journal of Gastroenterology : WJG·Dorota Czerucka, Patrick Rampal

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