PMID: 13549639Jul 1, 1958Paper

Studies on the transfer of lymph node cells. XI. Effect on the anti-Shigella agglutinin titers of recipient rabbits of the prior injection of leucocytes from the donor animals

The Journal of Experimental Medicine
T N HarrisM B FARBER

Abstract

The transfer to rabbits of homologous lymph node cells which have been incubated in vitro with Shigella-trypsin filtrate leads to the appearance of agglutinins to Shigella in the sera of the recipients. In the present study it has been found that the prior injection of the prospective recipients with blood leucocytes from the donor animals prevented the appearance of anti-Shigella agglutinins. The following observations have been made in this system: 1. The degree of the pre-injection effect was found to be a function of the number of leucocytes injected and of the interval between such pre-injection and the transfer of the antigen-incubated lymph node cells. 2. The pre-injection of leucocytes at appropriate intervals could also cause the failure of antibody to appear in sera of recipients of lymph node cells when these were obtained from donor rabbits injected with Shigella, 1, 2, or 3 days prior to cell transfer. 3. Agglutinins failed to appear in cell-transfer experiments after the pre-injection not only of blood leucocytes, but also of lymph node cells, peritoneal exudate cells, or thymus cells of rabbits. This effect was not brought about by pre-injection of erythrocytes of rabbits or leucocytes of chicken, cow, or horse. ...Continue Reading

References

Sep 8, 1956·Nature·R E BILLINGHAMP B MEDAWAR
May 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·T N HARRISM B FARBER

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Citations

Sep 3, 1964·The New England Journal of Medicine·P S RUSSELL, A P MONACO
Mar 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·F CELADA, W J WELSHONS
Nov 1, 1962·The Journal of Experimental Medicine·T N HARRISM B FARBER
Nov 30, 1964·Annals of the New York Academy of Sciences·T N HARRISM B FARBER
Jun 30, 1960·Annals of the New York Academy of Sciences·T N HARRIS, S HARRIS

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