Studies on the trypanocidal activity of semi-synthetic pyran[b-4,3]naphtho[1,2-d]imidazoles from beta-lapachone

European Journal of Medicinal Chemistry
Kelly C G de MouraS L De Castro

Abstract

We synthesized new naphthoimidazoles from beta-lapachone with an aromatic moiety linked to the imidazole ring, using phenylic and heterocyclic aldehydes. The most active compound against Trypanosoma cruzi had a p-methyl group linked to the phenyl ring, presenting an EC(50) value of 15.5 +/- 2.9 microM. No reliable correlation could be established with the biological activity and the structure of in the phenylic series. For the heterocyclic series, activity was associated with a three bond-distance from nitrogen to the imidazole ring, in accordance with our previous work.

References

Jan 1, 1989·Free Radical Biology & Medicine·A Brunmark, E Cadenas
May 7, 2002·Memórias do Instituto Oswaldo Cruz·José Rodriques Coura, Solange L de Castro

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Citations

Oct 8, 2013·European Journal of Medicinal Chemistry·Solange L de CastroEufrânio N da Silva Júnior
Mar 14, 2009·Parasitology·R F S Menna-BarretoS L De Castro
Jan 25, 2006·Nucleic Acids Research·Xiaochun Shi, Jonathan B Chaires
Apr 6, 2006·Parasitology Research·Alessandra JorqueiraSaulo C Bourguignon
Aug 24, 2016·PLoS Neglected Tropical Diseases·Giselle Villa Flor BrunoroRubem Figueiredo Sadok Menna-Barreto
Oct 14, 2008·Micron : the International Research and Review Journal for Microscopy·Rubem F S Menna-BarretoSolange L de Castro
Jul 23, 2015·Revista Do Instituto De Medicina Tropical De São Paulo·Taís Mata-SantosCarlos James Scaini
Jul 6, 2015·European Journal of Medicinal Chemistry·André A VieiraEufrânio N da Silva
Aug 20, 2015·Organic & Biomolecular Chemistry·Elumalai GopiIrishi N N Namboothiri
Jun 26, 2010·Organic & Biomolecular Chemistry·Sven ClaessensNorbert De Kimpe
Sep 15, 2010·Organic & Biomolecular Chemistry·Vitor Francisco FerreiraFernando de Carvalho da Silva
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·Maria de Nazaré C SoeiroSolange Lisboa de Castro
Nov 5, 2005·The Journal of Antimicrobial Chemotherapy·Rubem F S Menna-BarretoSolange L De Castro
Mar 22, 2020·Journal of Bioenergetics and Biomembranes·Caroline Deckmann NicolettiVitor Francisco Ferreira
Feb 20, 2020·Memórias do Instituto Oswaldo Cruz·Cynthia M CascabulhoRubem Fs Menna-Barreto
Nov 8, 2020·European Journal of Medicinal Chemistry·Qijie GongXiaojin Zhang
Jan 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ana Cristina S BombaçaRubem F S Menna-Barreto
Apr 3, 2021·Bioorganic Chemistry·Claudia López-LiraEugenio Uriarte
Jun 26, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Gleiston G DiasEufrânio N da Silva Júnior
Jun 9, 2009·Free Radical Biology & Medicine·Rubem F S Menna-BarretoSolange L de Castro
Apr 1, 2011·European Journal of Medicinal Chemistry·Sabrina Baptista FerreiraSolange L de Castro

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