PMID: 653733Feb 1, 1978Paper

Studies on the uptake and metabolism of dibenz(b,f)-1,4-oxazepine (CR) by guinea-pig cornea

Toxicology
J K Balfour

Abstract

The uptake and metabolic fate of the sensory irritant dibenz(b,f)-1,4-oxazepine (CR) have been investigated in intact cornea and corneal homogenates using 3H-labelled CR. The cornea metabolises CR to its lactam derivative (10,11-dihydro-10-oxo-dibenz(b,f)-1,4-oxazepine) by a process which appears to be located in the cell cytoplasm and which is easily saturated. Uptake studies with higher concentrations of [3H]CR (1 X10(-5) M) which saturate lactam biosynthesis, suggest that CR may bind, with low affinity, to sites within the corneal cells. The possible roles of CR metabolism and CR binding in chemical sensory irritation are discussed.

References

Oct 1, 1975·Toxicology and Applied Pharmacology·R H RengstorffV M Sim
Nov 1, 1974·Acta Pharmacologica Et Toxicologica·B Ballantyne, D W Swanston
Jan 1, 1972·Archives of Environmental Health·C E UlrichY Alarie
Jan 1, 1965·Cold Spring Harbor Symposia on Quantitative Biology·L M Beidler

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Citations

Dec 18, 2001·Journal of Applied Toxicology : JAT·E J Olajos, H Salem
Jan 1, 1982·Clinical and Experimental Pharmacology & Physiology·J E Gardiner, H S Lee
Jun 1, 1983·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B FurnivalD G Upshall

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