PMID: 4400698Feb 1, 1972Paper

Studies on thymus function. 3. Duration of thymic function

The Journal of Experimental Medicine
O StutmanR A Good


The immune functions of neonatally thymectomized C3Hf mice exposed only temporarily to thymus function show a progressive decay with time in the absence of the thymus. The immune responses studied at different ages in the range of 100-600 days were: first-set rejection of H-2-compatible and incompatible skin allografts, second-set rejection of skin allografts, capacity of spleen cells to produce graft-versus-host reactions in F(1) hybrids, resistance to infection with mouse hepatitis virus, and response of spleen cells to phytohemagglutinin in vitro. These long-term studies had the purpose of determining the duration of the restoration induced by thymus function when the mice were exposed only temporarily to it. Different models were used but the two basic ones were: (a) mice grafted intraperitoneally at 15 days of age with a syngeneic thymus that was removed surgically at 10, 20, or 30 days after grafting, and (b) mice grafted at 15 days of age with allogeneic strain A thymoma or C57BL thymus, these representing situations in which there is spontaneous rejection of the restoring graft. In all the experimental models used, the animals were restored when tested at 100 days of age, but progressively became immunologically incapac...Continue Reading


Apr 1, 1967·The Journal of Experimental Medicine·R GallilyF B Bang
Dec 1, 1963·The Journal of Experimental Medicine·J EASTA POMERANCE
Apr 1, 1965·The Journal of Experimental Medicine·E J YunisR A Good


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