Studies on tocopherol derivatives: V. Intestinal absorption of several d,1-3,4-3H2-alpha-tocopheryl esters in the rat.

Lipids
T NakamuraG Katsui

Abstract

Twelve d,1-3,4-3H2-alpha-tocopheryl esters were synthesized from d,1-3,4-3H2-alpha-tocopherol. They were acetate, propionate, butyrate, isobutyrate, caprylate, palmitate, acid succinate, benzoate, nicotinate, o-hydroxybenzoate, o-acetoxybenzoate, and pivalate. The hydrolysis of these esters with bile-pancreatic juice and with 9,000 x g supernatant of small intestine and liver homogenates of rats was examined. When these esters were incubated in small intestine or liver supernatants, hydrolysis occurred at a similar rate. In the incubation experiments, alpha-tocopheryl acetate, propionate, butyrate, isobutyrate, caprylate, palmitate, and acid succinate were classified as an easily hydrolyzable group. Alpha-tocopheryl benzoate and nicotinate were in a moderately hydrolyzable group. O-hydroxybenzoate and pivalate, which resisted hydrolysis, were in a scarcely hydrolyzable group. O-acetoxybenzoate was easily hydrolyzed to the o-hydroxybenzoate. Hydrolysis on straight chain fatty acid esters of alpha-tocopherol easily occurred in bile-pancreatic juice. In in vivo experiments, the lymphatic absorption rate of 6 esters, acetate, palmitate, acid succinate, nicotinate, o-hydroxybenzoate, and pivalate, was measured on thoracic duct fistu...Continue Reading

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Citations

Dec 8, 2004·Molecular Nutrition & Food Research·Claus Schneider
Mar 1, 1994·Free Radical Biology & Medicine·T KanekoM Matsuo
Apr 7, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·G NeunertK Polewski
May 20, 2008·Chemistry and Physics of Lipids·Lydie BrissonEl Hassan Ajandouz
Jul 12, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Stéphane CastanEl Hassan Ajandouz
Mar 25, 2017·Antioxidants·Kimbell R Duncan, Yuichiro J Suzuki
Oct 16, 2018·Medicinal Research Reviews·Milica MarkovicArik Dahan

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