Studies on transdermal delivery enhancement of zidovudine.

AAPS PharmSciTech
Evrim Atilay TakmazTamer Baykara

Abstract

The purpose of this study was to investigate physicochemical characteristics and in vitro release of zidovudine from monolithic film of Eudragit RL 100 and ethyl cellulose. Films included 2.5% or 5% (w/w) zidovudine of the dry polymer weight were prepared in various ratios of polymers by solvent evaporation method from methanol/acetone solvent mixture. The release studies were carried out by vertical Franz cells (2.2 cm(2) area, 20 ml receptor fluid). Ex vivo studies were done on Wistar rat skin within the films F6 (Eudragit RL100) and F7 (Eudragit RL100/Ethylcellulose, 1:1) consisting 5% (w/w) zidovudine in comparison with the same amount of free drug. Either iontophoresis (0.1 and 0.5 mA/cm(2) direct currents, Ag/AgCl electrodes) or dimethyl sulfoxide (pretreatment of 1% and 5%, w/w, solutions) were used as enhancers. Films consisting of ethyl cellulose under the ratio of 50% (w/w) gave similar release profiles, and the highest in vitro cumulative released amount was achieved with F6 film which gave the closest results with the free drug. This result could be due to the high swelling capacity and re-crystallization inhibition effect of RL 100 polymer which also influenced the film homogenization. All the films were fitted to ...Continue Reading

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Citations

Sep 16, 2010·AAPS PharmSciTech·Jucimary V SantosMaria Eugénia Tavares Pina
Mar 25, 2014·Journal of Nanobiotechnology·Jimma Likisa LenjisaGizaw Dabessa Satessa
Mar 24, 2012·Drug Development and Industrial Pharmacy·Jucimary V SantosLuís A E Batista de Carvalho
Apr 29, 2014·Expert Opinion on Drug Delivery·Francesco CilurzoPaola Minghetti
Sep 21, 2010·Drug Development and Industrial Pharmacy·Rachna RastogiVeena Koul
Feb 19, 2015·Therapeutic Delivery·Anthony S Ham, Robert W Buckheit
May 26, 2016·Journal of Pharmaceutical Sciences·André Luis Menezes CarvalhoDavi Pereira de Santana
Jul 4, 2021·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Irene de Jesús Martínez-Segoviano, Adriana Ganem-Rondero

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