PMID: 1201377Oct 1, 1975Paper

Studies upon the mechanism by which acetylcholine releases surplus acetylcholine in a sympathetic ganglion

British Journal of Pharmacology
B Collier, H S Katz

Abstract

1. Acetylcholine (ACh) releases surplus ACh from the superior cervical ganglion of the cat and the experiments described in this paper tested whether this results from exchange of endogenous ACh with exogenous ACh; the experiments also attempted to characterize pharmacologically the mechanism of this action of ACh. 2. The surplus ACh in the ganglion was radioactively labelled by perfusion of the ganglion with [3H]-choline-Krebs solution containing diisopropylphosphofluoridate, and the release of surplus [3H]-ACh by [14C]-ACh injected close arterially to the ganglion measured. The amount of [3H]-ACh released by [14C]-ACh was 33 +/- 5 times greater than was the amount of [14C]-ACh accumulated by ganglia. The amount of exogenous ACh accumulated by ganglia that had first formed surplus ACh was not different from exogenous ACh accumulation by ganglia that had not formed surplus ACh. Thus, it is concluded that surplus ACh release by ACh is not the result of ACh exchange. 3. In other experiments, surplus [3H]-ACh was accumulated in ganglia exposed to physostigmine. Nicotine, pilocarpine or ACh released surplus ACh; the effect of both nicotine and ACh was blocked by hexamethonium; atropine blocked the effect of ACh but not that of nico...Continue Reading

References

May 1, 1971·The Journal of Physiology·B Collier, H S Katz
Jun 1, 1970·British Journal of Pharmacology·B Collier, H S Katz
Oct 1, 1972·The Biochemical Journal·R M Marchbanks, M Israël
Dec 1, 1972·The Biochemical Journal·L A BarkerV P Whittaker
Dec 1, 1972·The Biochemical Journal·M J DowdallV P Whittaker
Jun 1, 1974·Journal of Neurochemistry·M J Kuhar, J R Simon
Mar 1, 1971·Journal of Neurochemistry·R M Marchbanks, M Israël
Feb 1, 1969·Canadian Journal of Physiology and Pharmacology·B Collier, C Lang
Nov 1, 1967·Biochemical Pharmacology·C C PorterC A Stone
Mar 25, 1943·The Journal of Physiology·W Feldberg
Jun 9, 1934·The Journal of Physiology·W Feldberg, J H Gaddum
Dec 11, 1936·The Journal of Physiology·G L Brown, W Feldberg

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Citations

Jan 1, 1988·Pharmacology & Therapeutics·F Mitchelson
Jan 1, 1979·Progress in Neurobiology·M IsraelR Manaranche
Apr 15, 1999·Annual Review of Neuroscience·A B MacDermottS A Siegelbaum
Feb 9, 2007·The Tohoku Journal of Experimental Medicine·Tuncay NasYusuf Sarioğlu
Feb 8, 2007·Respiratory Physiology & Neurobiology·Machiko ShirahataRobert S Fitzgerald
Nov 19, 2002·Journal of Neurobiology·Mariella De Biasi

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