PMID: 6983967Sep 1, 1982Paper

Studies with a spontaneous murine tumour--I. Indetectibility of host immune resistance with tumour-activated elaboration of T cell stimulatory lymphokines in vitro

European Journal of Cancer & Clinical Oncology
K D Chandradasa, J Blears

Abstract

A spontaneous tumour SP/N-1 which arose in a BALB/c female mouse and histologically consistent with breast origin was studied in vivo and in vitro to assess host responses to the tumour. Examination by means of the established methods of tumour cell challenge and cell transfer assays following 'immunization' of the isogeneic host against the tumour failed to provide clear evidence of host recognition and reactivity. Cell transfers conducted using critical numbers of tumour cells in which tumour to spleen cell ratios of up to 1:1000 were employed did not show any sign of antitumour activity within the pretreated host spleen cells. Nor was there any evidence of host resistance when presensitized mice were challenged with graded doses of tumour cells ranging from 10(4) cells, with no take of tumours, to 5 X 10(4) cells, with total acceptance of the tumour by the challenged mice. Despite failures to demonstrate clear immune recognition of tumour by the above criteria, normal spleen cells when incubated with the tumour cells in vitro elaborated factors with stimulatory and possibly suppressive properties. At least one of these factors was shown to stimulate T cells as evidenced by stimulation of DNA synthesis in thymocytes. This cou...Continue Reading

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Citations

Oct 1, 1983·Clinical & Experimental Metastasis·P NanniG Prodi
Mar 8, 2000·Patient Education and Counseling·L Sherliker, A Steptoe
Dec 30, 1994·Breast Cancer : the Journal of the Japanese Breast Cancer Society·M NoguchiI Miyazaki
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Mar 22, 2002·Veterinary Ophthalmology·W A BeltranB Clerc
Sep 25, 2010·Veterinary Ophthalmology·Nuh KiliçSule Yurdagül Ozsoy
Dec 20, 2005·Veterinary Ophthalmology·Aline A BolzanJosé L Laus
Feb 1, 1989·Journal of in Vitro Fertilization and Embryo Transfer : IVF·D T ArmstrongL Denver

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