PMID: 3973064Jan 1, 1985

Studies with stable isotopes II: Phenobarbital pharmacokinetics during monotherapy

Journal of Clinical Pharmacology
T R BrowneD J Greenblatt

Abstract

Six healthy adults receiving no other medications were given tracer doses of 90 mg of stable isotope-labeled phenobarbital (PB) intravenously before, and four weeks after, and 12 weeks after beginning therapy. Serum samples were collected for 96 hours after each injection, and the concentration of stable isotope-labeled PB in each sample was determined by gas chromatographic mass spectrometry. The volume of distribution, elimination half-life, and total clearance of PB did not differ significantly on any of the three occasions measured. Phenobarbital clearance did not correlate significantly with total PB serum concentration. Clearances determined from single-dose studies before beginning PB therapy accurately predicted steady-state PB serum concentrations. Therefore, it is not necessary to adjust PB dosage for time-dependent or dose-dependent changes in clearance during monotherapy. In addition, clearance or serum concentration determined at one dosing rate directly predicts serum concentration at another dosing rate.

References

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Citations

Apr 29, 1998·Journal of Clinical Pharmacology·T R Browne
Jan 1, 1990·Journal of Pharmaceutical and Biomedical Analysis·W H SoineJ H Wood
Jan 10, 2002·Journal of Pharmaceutical Sciences·Patrick Poulin, Frank-Peter Theil
Nov 9, 2011·Advanced Drug Delivery Reviews·Cecilie Johannessen LandmarkTorbjörn Tomson
Dec 1, 1987·Journal of Veterinary Pharmacology and Therapeutics·W R RavisJ Schumacher
Jul 1, 1986·Journal of Clinical Pharmacology·T R Browne
Jul 1, 1986·Journal of Clinical Pharmacology·T R BrowneG E Schumacher
Jan 1, 1985·Journal of Clinical Pharmacology·T R BrowneG E Schumacher
May 1, 1985·Journal of Clinical Pharmacology·J E EvansD J Greenblatt
Jun 7, 2002·AAPS PharmSci·Patrick J McNamara, Jane Alcorn
Jan 1, 1985·Journal of Clinical Pharmacology·T R BrowneD J Greenblatt
Mar 1, 2002·Biopharmaceutics & Drug Disposition·A MirfazaelianM Mahmoudian
Mar 11, 2020·Frontiers in Veterinary Science·Liana M YatesMunashe Chigerwe

Related Concepts

Carbon Isotopes
Dose-Response Relationship, Drug
Chromatography, Gas-Liquid-Mass Spectrometry
Nitrogen Isotopes
Luminal
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