Abstract
Apixaban, one of the non-vitamin K antagonist oral anticoagulants, was reported to be effective and safe in stroke prevention in patients with atrial fibrillation (AF) based on the global randomized clinical trial, but data are limited on the efficacy and safety of apixaban in Japanese elderly patients. The J-ELD AF Registry is a large-scale, contemporary observational study, continuously and prospectively registering elderly Japanese patients with AF aged 75 years or older who are currently taking apixaban or the elderly who are to receive apixaban in daily clinical practice, and accumulating the outcomes during one-year follow-up period. In addition to standard baseline characteristics, prothrombin time and anti-Xa activity will be measured to investigate the biomarker characteristics. The primary efficacy endpoints will be stroke and systemic embolism, and the primary safety endpoint will be major bleeding requiring hospitalization. The secondary endpoints in this study will be all-cause death, cardiovascular death, acute myocardial infarction, and the composite of stroke/systemic embolism, cardiovascular death, and acute myocardial infarction. As a primary analysis, the primary/secondary endpoints in the enrolled patients w...Continue Reading
References
Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Sep 12, 2003·The New England Journal of Medicine·Elaine M HylekDaniel E Singer
Nov 1, 2005·Journal of the American College of Cardiology·Albert L WaldoUNKNOWN NABOR Steering Committee
Mar 11, 2006·Stroke; a Journal of Cerebral Circulation·Elaine M HylekSusan Regan
Aug 12, 2008·International Journal of Cardiology·Hiroshi InoueShiro Kamakura
Dec 25, 2009·Circulation. Cardiovascular Quality and Outcomes·Adam J RoseElaine M Hylek
Jul 9, 2010·The American Journal of Medicine·Isla M OgilvieGregory Y H Lip
Feb 12, 2011·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN AVERROES Steering Committee and Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Aug 31, 2012·European Heart Journal·Stefan H HohnloserLars Wallentin
Feb 14, 2013·Journal of cardiology·Masaharu AkaoUNKNOWN Fushimi AF Registry Investigators
Nov 21, 2013·The New England Journal of Medicine·Robert P GiuglianoUNKNOWN ENGAGE AF-TIMI 48 Investigators
Dec 10, 2013·Lancet·Christian T RuffElliott M Antman
Feb 25, 2014·European Heart Journal·Sigrun HalvorsenLars Wallentin
Aug 30, 2014·Journal of cardiology·Takeshi YamashitaUNKNOWN J-RHYTHM Registry Investigators
Sep 1, 2014·American Heart Journal·Shinya GotoUNKNOWN ARISTOTLE Investigators
Feb 15, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yuji KatoUNKNOWN Japan Standard Stroke Registry Study Group
Citations
Sep 16, 2019·Heart and Vessels·Shinya SuzukiTakeshi Yamashita
Nov 19, 2019·Clinical Cardiology·Ken OkumuraUNKNOWN J-ELD AF Investigators
Jul 21, 2020·International Heart Journal·Takuto AritaTakeshi Yamashita
Apr 17, 2018·Journal of Arrhythmia·Satoshi OgawaLyo Inuyama
May 28, 2019·Heart and Vessels·Shinya SuzukiTakeshi Yamashita
May 27, 2020·European Journal of Clinical Pharmacology·Shinya SuzukiUNKNOWN J-ELD AF investigators
Jan 25, 2021·Heart and Vessels·Masaharu AkaoUNKNOWN J-ELD AF Investigators
May 21, 2021·European Journal of Clinical Pharmacology·Shinya SuzukiKen Okumura
Jul 30, 2021·Journal of the American Heart Association·Masato OkadaUNKNOWN J‐ELD AF investigators
Apr 8, 2018·Journal of cardiology·Hiroshi InoueAtsushi Takita