Study Design of the Graft Patency After FFR-Guided Versus Angiography-Guided CABG Trial (GRAFFITI)

Journal of Cardiovascular Translational Research
Gabor G TothEmanuele Barbato

Abstract

Clinical benefit of invasive functionally guided revascularization has been mostly investigated and proven for percutaneous coronary intervention. It has never been prospectively evaluated whether a systematic fractional flow reserve (FFR) assessment is also beneficial in guiding coronary artery bypass graft surgery (CABG). The objective of the GRAft patency after FFR-guided versus angiography-guIded CABG (GRAFFITI) trial was to compare an FFR-guided revascularization strategy to the traditional angiography-guided revascularization strategy for patients undergoing CABG. Patients were enrolled with significantly diseased left anterior descending or left main stem and at least one major coronary artery with angiographically intermediate stenosis (30-90% diameter stenosis) that was assessed by FFR. Thereafter, while the FFR values were kept concealed, cardiac surgeons decided their intended procedural strategy based on the coronary angiography alone. At this point, patients underwent 1:1 randomization to either an FFR-guided or an angiography-guided CABG strategy. In case the patient was randomized to angiography-guided arm, cardiac surgeons kept their intended procedural strategy, i.e., CABG was guided solely on the basis of the ...Continue Reading

Associated Clinical Trials

References

Aug 31, 2010·European Heart Journal·UNKNOWN Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for CardDavid Taggart
Sep 28, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·UNKNOWN Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for CardDavid Taggart
Mar 20, 2014·European Heart Journal·Gabor TothBernard De Bruyne
Sep 2, 2014·The New England Journal of Medicine·Bernard De BruyneUNKNOWN FAME 2 Trial Investigators
May 23, 2018·The New England Journal of Medicine·Panagiotis XaplanterisUNKNOWN FAME 2 Investigators

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Citations

Jun 7, 2019·European Heart Journal·Morton J Kern, Arnold H Seto
Aug 30, 2019·Current Opinion in Cardiology·Etem CaliskanVolkmar Falk
May 16, 2019·Circulation. Cardiovascular Interventions·Stephane FournierEmanuele Barbato
Jul 5, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Gabor G TothEmanuele Barbato
Oct 1, 2018·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Om Prakash Yadava, Filip Casselman
Jun 10, 2019·The Thoracic and Cardiovascular Surgeon·Christopher GestrichFritz Mellert
Mar 9, 2021·General Thoracic and Cardiovascular Surgery·Michiko IshidaYasushi Takagi
Apr 11, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Stephane FournierEmanuele Barbato

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