Study of 106 organic and inorganic compounds in the Salmonella/microsome test

Carcinogenesis
S de Flora

Abstract

One hundred and six compounds, subdivided into 12 chemical classes (5 polycyclic aromatic hydrocarbons, 7 epoxides and N-oxides, 5 nitro aromatics and heterocycles, 12 aromatic and heterocyclic amines, 2 azo compounds, 17 hydrazine derivatives, 16 miscellaneous aliphatics, 5 miscellaneous heterocycles, 11 miscellaneous organics, 11 hexavalent and 7 trivalent chromium compounds, 8 miscellaneous inorganics), were studied in the Salmonella/microsome test. Fifty-eight of them (54.7%) were found to be mutagenic and 4 additional compounds (3.8%) yielded a positive response following nitrosation in human gastric juice. The results are presented in a tabulated form, providing the following information for each test compound: (a) mutagenic response in 5 S. typhimurium his- strains (TA1535, TA1537, TA1538, TA98, TA100); (b) range of activity for positive compounds or maximum dose tested for negative compounds (in nmol/plate); (c) mutagenic potency (in revertants/nmol compound), varying over a 6.5 x 10(6)-fold range; (d) effect of S-9 mix containing rat (Aroclor)liver S-9 fractions on the mutagenic response (activation, increase, no change or decrease); (e) remarks concerning the influence of other metabolic systems (up to 10 different ra...Continue Reading

Citations

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