Study of a 13-weeks, Repeated, Intramuscular Dose, Toxicity Test of Sweet Bee Venom in Sprague-Dawley Rats

Journal of Pharmacopuncture
Hyunmin KangKwangho Lee

Abstract

This study was performed to analyze a 13-week repeated dose toxicity test of Sweet Bee Venom (SBV) extracted from bee venom and administered in Sprague-Dawley (SD) rats. Male and female 5-week-old SD rats were treated once daily with SBV (high-dosage group: 0.28 mg/kg; medium-dosage group: 0.14 mg/kg; or low-dosage group: 0.07 mg/kg) for 13 weeks. Normal saline was administered to the control group in a similar manner (0.2 mL/kg). We conducted clinical observations, body weight measurements, ophthalmic examinations, urinalyses, hematology and biochemistry tests, and histological observations using hematoxylin and eosin (H&E) staining to identify any abnormalities caused by the SBV treatment. During this study, no mortality was observed in any of the experimental groups. Hyperemia and a movement disorder were observed around the area of in all groups that received SBV treatment, with a higher occurrence in rats treated with a higher dosage. Male rats receiving in the high-dosage group showed a significant decrease in weight during the treatment period. Compared to the control group, no significant changes in the ophthalmic parameters, the urine analyses, the complete blood cell count (CBC), and the biochemistry in the groups tre...Continue Reading

References

Jan 15, 1976·European Journal of Biochemistry·J GauldieC A Vernon
Jul 1, 1992·Journal of Neuro-oncology·J K ChiuR Shallenberger
Jul 28, 1972·Science·E Habermann
Sep 1, 2003·Irish Journal of Psychological Medicine·Conor O'NeillBrian A Lawlor

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Citations

Sep 22, 2015·Journal of Pharmacopuncture·Kwang-Ho LeeKiRok Kwon
Oct 1, 2020·Toxins·Ting-Yen Lin, Ching-Liang Hsieh

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Methods Mentioned

BETA
blood collection

Software Mentioned

SAS

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