Study of an alginate/HPMC-based in situ gelling ophthalmic delivery system for gatifloxacin

International Journal of Pharmaceutics
Zhidong LiuWei-San Pan

Abstract

The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid pre-corneal elimination of the drug may be overcome by the use of in situ gel-forming systems that are instilled as drops into the eye and then undergo a sol-gel transition in the cul-de-sac. The present work describes the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent, gatifloxacin, based on the concept of ion-activated in situ gelation. Alginate (Kelton) was used as the gelling agent in combination with HPMC (Methocel E50Lv) which acted as a viscosity-enhancing agent. The rheological behaviors of all formulations were not affected by the incorporation of gatifloxacin. Both in vitro release studies and in vivo pre-corneal retention studies indicated that the alginate/HPMC solution retained the drug better than the alginate or HPMC E50Lv solutions alone. These results demonstrate that the alginate/HPMC mixture can be used as an in situ gelling vehicle to enhance ocular bioavailability and patient compliance.

References

Mar 1, 1995·Journal of Pharmaceutical Sciences·S Kumar, K J Himmelstein
Mar 31, 1998·Journal of Pharmaceutical Sciences·S D Desai, J Blanchard
Apr 16, 1998·Progress in Retinal and Eye Research·C L BourlaisR Leverge
Dec 5, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H R Lin, K C Sung
Aug 23, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·B SrividyaP D Amin
Jun 28, 2002·International Journal of Pharmaceutics·A H El-Kamel
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Th F Vandamme, L Brobeck

❮ Previous
Next ❯

Citations

Jun 12, 2008·Journal of Materials Science. Materials in Medicine·Wenguang LiuFengfu Li
Sep 2, 2008·Pharmaceutical Research·Ripal GaudanaAshim K Mitra
Jun 19, 2013·Pharmaceutical Research·Mohammed M IbrahimMonica M Jablonski
Oct 22, 2011·European Journal of Drug Metabolism and Pharmacokinetics·Basavaraj K NanjwadeF V Manvi
Jun 15, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Indu Pal KaurShilpa Kakkar
Nov 1, 2012·Indian Journal of Pharmaceutical Sciences·C Vijaya, K Swetha Goud
May 22, 2010·Indian Journal of Pharmaceutical Sciences·M MadanJ A Baig
Nov 3, 2012·International Journal of Pharmaceutical Investigation·Gaurav KhuranaPravin K Pawar
Nov 3, 2012·International Journal of Pharmaceutical Investigation·Sonjoy MandalMs Geetha
Jan 1, 2011·International Journal of Pharmaceutical Investigation·Ritu Mehra GilhotraDina Nath Mishra
Apr 23, 2013·Advanced Drug Delivery Reviews·Pietro MatricardiFranco Alhaique
Aug 16, 2014·International Journal of Pharmaceutical Investigation·Akhilesh Dubey, Prabhakara Prabhu
May 16, 2009·Expert Opinion on Therapeutic Patents·Xiao-Jie JuLiang-Yin Chu
Apr 11, 2008·Drug Development and Industrial Pharmacy·Satishkumar P JainPurnima D Amin
Feb 20, 2013·Expert Opinion on Drug Delivery·Pravin PawarDipak K Majumdar
Mar 22, 2012·Expert Opinion on Drug Delivery·Ashish Kumar AgrawalSanyog Jain
Nov 17, 2012·Drug Development and Industrial Pharmacy·Djamila AchouriVéronique Andrieu
Mar 18, 2009·Expert Opinion on Drug Delivery·Patrizia PaolicelliMaría José Alonso
Jun 19, 2012·Expert Opinion on Drug Delivery·Priyanka PahujaPravin Pawar
Sep 21, 2010·Drug Development and Industrial Pharmacy·Yong QianQunwei Xu
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Huda KhanA K Bajpai
Jan 8, 2013·Journal of Pharmaceutical Sciences·Mohammed Mostafa IbrahimMonica M Jablonski
Mar 2, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Taís GratieriRenata Fonseca Vianna Lopez
Jun 3, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Susanne KirchhofFerdinand P Brandl
Dec 25, 2010·Veterinary Ophthalmology·Alan L Weiner, Brian C Gilger
Mar 19, 2014·The Journal of Pharmacy and Pharmacology·Joel G SouzaRenata F V Lopez
Dec 28, 2011·Pharmaceutical Development and Technology·Prashant K Deshmukh, Surendra G Gattani
Sep 5, 2013·Colloids and Surfaces. B, Biointerfaces·Pavan SunkireddySubhash C Yadav
Dec 5, 2009·Advanced Drug Delivery Reviews·Maria de la FuenteMaria Jose Alonso
Aug 3, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pakama MahlumbaViness Pillay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
B SrividyaP D Amin
Journal of Controlled Release : Official Journal of the Controlled Release Society
Gang WeiJun Min Zheng
Journal of Controlled Release : Official Journal of the Controlled Release Society
Basavaraj K NanjawadeA S Manjappa
© 2022 Meta ULC. All rights reserved