Study of antibodies in paracoccidioidomycosis: follow-up of patients during and after treatment

Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology
M F Ferreira-da-CruzB Galvão-Castro

Abstract

The relevance of the humoral response in the prognosis of paracoccidioidomycosis was assessed by measuring the serological responses of individual patients to Paracoccidioides brasiliensis by double immunodiffusion (DID). Sixty-six patients with paracoccidiodomycosis were studied. Sera from 31 individuals were tested before and during treatment with sulfonamide (Group I). Sera from a further 35 individuals were tested after completion of a 2-year course of treatment (Group II). In Group I, clinical improvement was associated with a decrease in antibody titer in all patients. The only patient in this group who had a clinical relapse during specific treatment presented with a 4-fold increase in antibody titer immediately before relapse. In Group II, nine patients remained antibody positive at follow-up (61.9 +/- 40.0 months), despite their good physical health, indicating that the detection of antibodies to P. brasiliensis by the DID test does not necessarily indicate active disease. These data suggest that changes in antibody titers to P. brasiliensis detected by DID may be useful indicators of the extent of active disease. Measurement of antibody titers may be valuable for determining the prognosis of the infection and for deci...Continue Reading

References

Jan 1, 1976·Medical and Pediatric Oncology·K L Smith, G Rivera
Jul 1, 1985·Journal of Clinical Microbiology·K L McGowan, H R Buckley
Jan 1, 1987·Mycopathologia·M F Ferreire-da-CruzB Galvão-Castro
Jan 1, 1986·Revista Da Sociedade Brasileira De Medicina Tropical·C J SchofieldP D Marsden
Jan 24, 1983·The American Journal of Medicine·A RestrepoM A Robledo
Jan 1, 1962·Progress in Allergy·O OUCHTERLONY

❮ Previous
Next ❯

Citations

Nov 19, 2003·Microbes and Infection·Ademilson Panunto-CasteloMaria Cristina Roque-Barreira
Jan 1, 1993·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·G San-Blas
Oct 24, 2015·Diagnostic Microbiology and Infectious Disease·Julhiany de Fátima da SilvaMaria José Soares Mendes-Giannini
Aug 2, 2013·Memórias do Instituto Oswaldo Cruz·Gabriel Capella MachadoEduardo Bagagli
Nov 27, 1998·Revista Do Instituto De Medicina Tropical De São Paulo·A C do ValleL C da Cruz
Mar 1, 1995·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·G M del NegroC da S Lacaz
Sep 15, 2001·Medical Mycology·A C Do ValleR M Zancopé-Oliveira
Apr 1, 1993·Clinical Microbiology Reviews·E BrummerA Restrepo
Jun 1, 1991·Journal of Clinical Microbiology·M F Ferreira-da-CruzC T Daniel-Ribeiro
Jul 1, 1992·Infection and Immunity·M F Ferreira-da-CruzC Daniel-Ribeiro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology
M CasottoZ P Camargo
Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology
Z P CamargoL R Travassos
© 2021 Meta ULC. All rights reserved