Study of apoptosis in human liver cancers

World Journal of Gastroenterology : WJG
Chang-Min Shan, Juan Li

Abstract

To investigate the action of apoptosis in occurrence of liver carcinomas in vivo and the biological effect of Solanum lyratum Thumb on BEL-7404 cell line inducing apoptosis in vivo. The apoptosis in the liver carcinoma was detected with terminal deoxynucl neotidyl transferase mediated dUTP nick end labelling (TUNEL); the cancer cells cultured in DMED medium were treated with extract of Solanum lyratum Thumb and observed under microscope, and their DNA was assayed by gel electrophoresis. In vivo apoptotic cells in the cancer adjacent tissues inceased; in vivo treatment of liver cancers with extract of Solanum lyratum Thumb could induce the cells to manifest a typical apoptotic morphology. Their DNA was fractured and a characteristic ladder pattern could be found using electrophoresis. In vivo the apoptosis of carcinomas was lower; maybe the cells divided quickly and then the cancers occurred. In the cancer adjacent tissues,the apoptosis pricked up, and in vivo Solanum lyratum Thumb could induce the apoptosis of BEL-7404 cells.

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Citations

May 23, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Jai-Sing YangJing-Gung Chung
Jul 11, 2003·World Journal of Gastroenterology : WJG·Xiao-Dong ZhuZhong-Qing Chen
Mar 15, 2006·World Journal of Gastroenterology : WJG·Sarveswaran SivalokanathanMaruthaiveeran Periyasamy Balasubramanian
Aug 10, 2004·World Journal of Gastroenterology : WJG·Chi-Hua FangWei Zhang
Mar 4, 2010·Human & Experimental Toxicology·Jai-Sing YangJing-Gung Chung
Sep 13, 2003·World Journal of Gastroenterology : WJG·Zhi-Su LiuZhong-Li Ai
Dec 27, 2003·World Journal of Gastroenterology : WJG·Guang JiaJ C Gaston Wu

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