Study of association between hypertensive disorders of pregnancy and the human coagulation factor XI gene

Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Ichiro SatoTatsuo Yamamoto

Abstract

Hypertensive disorders of pregnancy (HDP) are among the most common and serious complications of pregnancy. Persuasive evidence implicaties genetic factors in the genesis of HDP. The aim of the present study was to assess the association between single-nucleotide polymorphisms (SNPs) in the human coagulation factor XI (F11) gene and HDP, by conducting a haplotype-based case-control study. We chose 3 SNPs (rs925453, rs925451, and rs12500151) in the human F11 gene as genetic markers. We then conducted an association study with 77 HDP patients and 154 age-matched non-HDP subjects. The frequency of rs925453 genotypes significantly differed between the two groups. The frequency of the T-G-G haplotype was significantly higher in the HDP group than in the non-HDP group (p = 0.0002). The T allele of rs925453 and the T-G-G haplotype appear to be useful genetic markers of HDP.

References

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Citations

Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masaaki TamuraTatsuo Yamamoto
Oct 24, 2009·Endocrine Journal·Tomohiro Nakayama, Tatsuo Yamamoto
Mar 17, 2009·Biochemical and Biophysical Research Communications·Naoyuki SatoMitsuko Yuzawa
Jun 14, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Sophie Wiewel-VerschuerenRené Mulder
Dec 11, 2007·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·L A MageeFor The Chips Pilot Trial Collaborative Group
Jul 14, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Frédéric Bauduer, Catherine Poumier-Chabanier
Jan 19, 2021·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Ai KonoKei Kawana

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