Study of Bone Surface Absorbed Dose in Treatment of Bone Metastases via Selected Radiopharmaceuticals: Using MCNP4C Code and Available Experimental Data

Cancer Biotherapy & Radiopharmaceuticals
Reza BagheriAli Bahrami Samani

Abstract

Bone metastases are major clinical concern that can cause severe problems for patients. Currently, various beta emitters are used for bone pain palliation. This study, describes the process for absorbed dose prediction of selected bone surface and volume-seeking beta emitter radiopharmaceuticals such as (32)P, (89)SrCl2,(90)Y-EDTMP,(153)Sm-EDTMP, (166)Ho-DOTMP, (177)Lu-EDTMP,(186)Re-HEDP, and (188)Re-HEDP in human bone, using MCNP code. Three coaxial sub-cylinders 5 cm in height and 1.2, 2.6, and 7.6 cm in diameter were used for bone marrow, bone, and muscle simulation respectively. The *F8 tally was employed to calculate absorbed dose in the MCNP4C simulations. Results show that with injection of 1 MBq of these radiopharmaceuticals given to a 70 kg adult man, (32)P, (89)SrCl2, and (90)Y-EDTMP radiopharmaceuticals will have the highest amount of bone surface absorbed dose, where beta particles will have the greatest proportion in absorbed dose of bone surface in comparison with gamma radiation. These results demonstrate moderate agreement with available experimental data.

References

Feb 1, 1976·The British Journal of Radiology·F W SpiersS D King
Jan 1, 1992·Seminars in Nuclear Medicine·J A Campa, R Payne
Jan 1, 1991·European Journal of Nuclear Medicine·C A Hoefnagel
Jan 1, 1989·European Journal of Nuclear Medicine·J H TurnerP G Claringbold
Mar 1, 1987·The Journal of Bone and Joint Surgery. British Volume·M GiladiZ Aharonson
Jun 14, 2000·Cancer Biotherapy & Radiopharmaceuticals·M M BialkowskiA T Porter
Sep 7, 2001·Seminars in Oncology·N Janjan
May 6, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Carlo L MainiRosa Sciuto
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sten NilssonOyvind S Bruland
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert E Coleman
Jan 24, 2007·European Journal of Nuclear Medicine and Molecular Imaging·L StrigariC L Maini
Sep 7, 2007·Cancer Biotherapy & Radiopharmaceuticals·Orazio SchillaciKathleen R Lamborn
May 6, 2008·Cancer Biotherapy & Radiopharmaceuticals·Sudipta ChakrabortyMaroor R A Pillai
Sep 25, 2010·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·L VignaM Brambilla
Dec 24, 2010·Scientia pharmaceutica·Ali Bahrami-SamaniMojtaba Shamsaee
May 31, 2012·Current Radiopharmaceuticals·M R A PillaiF F Knapp

❮ Previous
Next ❯

Citations

Jan 3, 2018·The British Journal of Radiology·Ana M Denis-BacelarGlenn D Flux

❮ Previous
Next ❯

Software Mentioned

MCNP4C
MCNP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.