Study of branched cationic beta-cyclodextrin polymer/indomethacin complex and its release profile from alginate hydrogel

International Journal of Pharmaceutics
Jianyu XinMaolin Li

Abstract

A series of branched cationic beta-cyclodextrin polymers (CPbetaCDs) with designed chemical structures were synthesized from beta-cyclodextrin (beta-CD), epichlorohydrin (EP) and choline chloride (CC). Indomethacin (IDM), an anionic drug, was chosen as a model drug to evaluate the drug loading capacities of CPbetaCDs. The formation of IDM-CPbetaCD complex was confirmed by (1)H NMR and DSC. Phase solubility studies and Job plots indicated that CPbetaCDs can solubilize IDM up to 100 times of its intrinsic solubility in a 1:1 complexation form. Mechanism studies with the help of adamantane revealed that the effective complexation is a combination of inclusion complexation, charge interaction and hydrophobic interaction. In addition, IDM-CPbetaCDs loaded alginate hydrogels were prepared and obtained controllable release profile in dissolution tests. The tunable structures of CPbetaCDs make them promising drug carriers with superior drug loading capacities and controllable drug release abilities.

References

Oct 1, 1996·Journal of Pharmaceutical Sciences·T Loftsson, M E Brewster
Feb 1, 1997·Journal of Pharmaceutical Sciences·T Irie, K Uekama
Mar 8, 2000·International Journal of Pharmaceutics·D C BibbyI G Tucker
Jun 6, 2000·Advanced Drug Delivery Reviews·S Wee, W R Gombotz
Jun 6, 2000·Advanced Drug Delivery Reviews·F Hirayama, K Uekama
Nov 30, 2000·Journal of Pharmaceutical and Biomedical Analysis·Y DotsikasY L Loukas
Apr 12, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·P Costa, J M Sousa Lobo
Jan 5, 2002·Advanced Drug Delivery Reviews·Akihiko Kikuchi, Teruo Okano
Feb 19, 2002·Chemical Reviews·József Szejtli
Feb 19, 2002·Chemical Reviews·Allan R. Hedges
Feb 19, 2002·Chemical Reviews·Kaneto UekamaTetsumi Irie
Oct 16, 2002·Journal of Pharmaceutical Sciences·Y NagaseK Uekama
Jun 16, 2004·International Journal of Pharmaceutics·Jianshu LiYinPing Zhong
Dec 2, 2004·Nature Reviews. Drug Discovery·Mark E Davis, Marcus E Brewster
Jan 31, 2006·Bioorganic & Medicinal Chemistry Letters·Cécile Binkowski-MachutEric Monflier
Nov 4, 2006·Advanced Drug Delivery Reviews·Chien-Chi Lin, Andrew T Metters
Nov 14, 2006·Advanced Drug Delivery Reviews·Davis Yohanes ArifinChi-Hwa Wang
Dec 2, 2006·International Journal of Pharmaceutics·Thorsteinn Loftsson, Dominique Duchêne
May 6, 2008·Computers in Biology and Medicine·Iosif-Daniel Rosca, Jean-Maurice Vergnaud
Nov 4, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·P J SalústioH M Cabral Marques

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Citations

Jul 2, 2014·Nanomedicine·Jaya Raju Lakkakula, Rui Werner Maçedo Krause
May 14, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·María Teresa Ramírez-SilvaGeorgina Alarcón-Angeles
May 8, 2015·Drug Development and Industrial Pharmacy·Bina Gidwani, Amber Vyas
May 31, 2011·Expert Opinion on Drug Delivery·Yiqing TangAndrew L Lewis
May 3, 2015·Carbohydrate Polymers·Jatupol JunthipBernard Martel
Nov 5, 2013·Colloids and Surfaces. B, Biointerfaces·Bina Gidwani, Amber Vyas
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Jaya R LakkakulaRui Werner Maçedo Krause
Oct 25, 2016·International Journal of Pharmaceutics·Safa OuerghemmiBernard Martel
Aug 26, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Banibrata MaityDebabrata Seth
Feb 26, 2016·Chemical Communications : Chem Comm·Guobao HuangWei Jiang
Feb 14, 2015·Chemical Communications : Chem Comm·Susana M N SimõesCarmen Alvarez-Lorenzo
Aug 14, 2012·Chemical Society Reviews·Sangram Keshari SamalPeter Dubruel
Nov 24, 2021·Topics in Current Chemistry·Chandan Maity, Nikita Das

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