Study of cardiac autonomic function in drug-naïve, newly diagnosed epilepsy patients

Epileptic Disorders : International Epilepsy Journal with Videotape
Peter MativoParthasarathy Satishchandra

Abstract

Epilepsy is associated with ictal autonomic dysfunction which may extend into the inter-ictal period. Antiepileptic drugs have often been blamed for cardiac autonomic dysfunction in epilepsy patients. In this study we have investigated cardiac autonomic parameters in order to evaluate autonomic functions of drug-naïve epilepsy patients. Twenty drug-naïve patients (15 males and 5 females) with epilepsy, and an equal number of age and gender matched controls, were evaluated for short-term resting heart rate variability and conventional cardiovascular autonomic measurements. The mean age of patients was 29.30 +/- 9.80 yrs (17-55 yrs), mean age at seizure onset was 19.70 +/- 9.15 yrs (3-40 yrs) and mean length of time since last seizure was 5.60 +/- 7.00 days (1-30 days). While there was no difference in the resting heart rate or conventional autonomic test parameters, time domain heart rate variability measurements showed a decreased percentage of R-R intervals of less than 50 ms and root mean square of R-R intervals in patients, when compared to controls. Frequency domain parameters showed a decreased total power (patients: 1,796.58 +/- 1,052.45 ms2; controls: 2,934.23 +/- 1,767.06 ms2, p = 0.008). Parameters indicative of decrea...Continue Reading

Citations

Jan 9, 2013·Journal of Clinical Monitoring and Computing·Hulegar A AbhishekhTalakad N Sathyaprabha
Jan 26, 2012·Current Opinion in Neurology·Rainer Surges, Josemir W Sander
Sep 6, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Morgayn I ReadIvan A Sammut
Sep 16, 2015·Acta Neurologica Scandinavica·A MeghanaP Satishchandra
Sep 6, 2015·Neurology·William SzurhajJulien De Jonckheere
Mar 6, 2021·Current Opinion in Neurology·Shobi Sivathamboo, Piero Perucca

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