Study of cardiovascular disease biomarkers among tobacco consumers. Part 3: evaluation and comparison with the US National Health and Nutrition Examination Survey

Inhalation Toxicology
Kristin M MaranoMichael F Borgerding

Abstract

Cardiovascular disease (CVD) biomarkers of biological effect (BoBE), including hematologic biomarkers, serum lipid-related biomarkers, other serum BoBE, and one physiological biomarker, were evaluated in adult cigarette smokers (SMK), smokeless tobacco consumers (STC), and non-consumers of tobacco (NTC). Data from adult males and females in the US National Health and Nutrition Examination Survey and a single site, cross-sectional study of healthy US males were analyzed and compared. Within normal clinical reference ranges, statistically significant differences were observed consistently for fibrinogen, C-reactive protein (CRP), hematocrit, mean cell volume, mean cell hemoglobin, hemoglobin, white blood cells, monocytes, lymphocytes, and neutrophils in comparisons between SMK and NTC; for CRP, white blood cells, monocytes, and lymphocytes in comparisons between SMK and STC; and for folate in comparisons with STC and NTC. Results provide evidence for differences in CVD BoBE associated with the use of different tobacco products, and provide evidence of a risk continuum among tobacco products and support for the concept of tobacco harm reduction.

References

Jul 1, 1991·Journal of Internal Medicine·M EliassonE Hägg
Jul 11, 1990·JAMA : the Journal of the American Medical Association·V L ErnsterW W Hauck
Jul 1, 1995·Journal of the American Dietetic Association·D W GiraudJ A Driskell
May 1, 1997·European Journal of Clinical Investigation·G BolinderU De Faire
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Ann ChaoEugenia E Calle
Jun 15, 2005·Cancer Causes & Control : CCC·S Jane HenleyEugenia E Calle
Aug 22, 2006·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Dorothy K HatsukamiStephen S Hecht
Nov 30, 2006·Scandinavian Journal of Public Health·Margareta NorbergLars Weinehall
Jan 30, 2009·Basic & Clinical Pharmacology & Toxicology·Gioacchino CalapaiAlfredo Nunziata
Feb 26, 2009·Tobacco Control·Mitchell ZellerUNKNOWN Strategic Dialogue on Tobacco Harm Reduction Group
Dec 15, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Dhouha Haj MouhamedMohamed Fadhel Najjar
Jan 18, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kenji Okumura, Hideto Tsukamoto
Feb 19, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kimberly Frost-PinedaMohamadi Sarkar
Feb 26, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Ziad S NaufalCody L Wilson
Mar 25, 2011·Annals of Nutrition & Metabolism·Mohammad Azam MansoorChris J Bates
Apr 10, 2014·European Addiction Research·David J NuttDavid Sweanor

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Citations

Nov 4, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Michael W OgdenMitchell F Stiles
Jan 4, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Michael John PeckRolf Weitkunat
Feb 2, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Daniel J ConklinAruni Bhatnagar
Oct 27, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·G L PrasadEvan O Gregg

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Clinical Trials Mentioned

NCT01692353

Software Mentioned

SAS®

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