Study of cardiovascular disease biomarkers among tobacco consumers, part 1: biomarkers of exposure

Inhalation Toxicology
Leanne R CampbellMichael F Borgerding

Abstract

A study was conducted to evaluate biomarkers of biological effect and physiological assessments related to cardiovascular disease (CVD) among adult male cigarette smokers (SMK), moist snuff consumers (MSC) and non-consumers of tobacco (NTC). Additionally, biomarkers of tobacco and tobacco smoke exposure (BoE) were measured in spot urines and are reported here. Except for the BoE to nicotine and NNK, BoE were generally greater in SMK compared with MSC, and BoE were generally not different in comparisons of MSC and NTC. Results demonstrated that MSC had lower systemic exposures to many harmful and potentially harmful constituents than SMK, which is consistent with epidemiological data that indicate a differential in CVD risk between these groups.

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Citations

Mar 10, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ronald AndersonMohammed Tikly
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Methods Mentioned

BETA
MDS
urine collection

Clinical Trials Mentioned

NCT01692353

Software Mentioned

SAS®

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