PMID: 7536373Nov 1, 1994Paper

Study of certain indicators of immunity upon infecting CBA/Calac line mice with Lassa virus

Voprosy virusologii
G M Ignat'evA T Godneva

Abstract

Some immunity parameters (interferon, tumor necrosis factor, interleukin 1, etc.) were studied in CBA/Calac mice infected with Lassa virus. The results permit a hypothesis that a pathologic inflammatory reaction is responsible for the death of animals in experimental Lassa fever. One of the components of this reaction is endogenous shock involving a manifest production of immune response mediators, such as interferon, interleukin 1. and tumor necrosis factor.

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