PMID: 3762525Jan 1, 1986Paper

Study of chromatin structure in ataxia-telangiectasia cells

Molecular Biology Reports
J HouldsworthM F Lavin

Abstract

Micrococcal nuclease was used as a probe to study chromatin structure in control and ataxia-telangiectasia cells. The rate and extent of release of acid-soluble nucleotide was similar in both cell types. Production of mono- and oligonucleosomes by micrococcal nuclease as determined by gel electrophoresis also failed to reveal differences in chromatin structure between control and ataxia-telangiectasia cells. Radiation exposure did not significantly alter the kinetics of digestion. These results indicate that there are no gross alterations in chromatin structure in ataxia-telangiectasia cells.

References

Dec 1, 1985·British Journal of Urology·T F FordR T Oliver
Jun 25, 1981·Nature·P Cramer, R B Painter
Jul 1, 1981·British Journal of Haematology·M C DelaucheM Seligmann
Dec 1, 1981·Mutation Research·M D FordM F Lavin
Mar 25, 1981·Nucleic Acids Research·M D Ford, M F Lavin
Aug 25, 1980·Nucleic Acids Research·J Houldsworth, M F Lavin

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