Study of Clinical Characteristics and Cytokine Profiles of Asthmatic Children with Rhinovirus Infection during Acute Asthma Exacerbation at National Hospital of Pediatrics

Canadian Respiratory Journal : Journal of the Canadian Thoracic Society
Thuy Nguyen-Thi-DieuSy Duong-Quy

Abstract

In children with asthma, the viral infection of airways is usually a main cause of acute asthma exacerbation and hospitalization. However, few studies on clinical and biomolecular characteristics of asthmatic children in this field have been done, especially in emergent countries. This study described the clinical and biological characteristics of asthmatic children who had acute asthma exacerbation and rhinovirus (RV) infection. Children under 15 years of age hospitalized for acute asthma exacerbation were included. They underwent clinical examination and peripheral blood analyses for the cytokine profile. The severity of acute asthma exacerbation was evaluated by Pediatric Asthma Score (PAS). Healthy children under 15 years of age were also invited in this study. One hundred fifteen asthmatic children were included in this study. There were 18.2% of mild PAS, 37.4% of moderate PAS, and 44.4% of severe PSA. Among them, 63/115 (54.8%) asthmatic children had positive RV infection (RV+). The percentages of asthmatic children with RV+ had increased polymorphonuclear leucocytes were significantly higher than asthmatic children with RV-. There were no significant differences of the concentrations of non-Th2-related cytokines in asth...Continue Reading

References

Oct 1, 1994·American Journal of Respiratory and Critical Care Medicine·C WalkerB Villiger
Jun 1, 1997·American Journal of Respiratory and Critical Care Medicine·J E GernW W Busse
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·H Z ShiZ F Xie
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·H E FlemingH A Boushey
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·K GrünbergP J Sterk
Jul 31, 2001·Journal of Clinical Pathology·J C Renauld
Jun 28, 2003·Viral Immunology·Mutsuo Yamaya, Hidetada Sasaki
Nov 13, 2004·The Journal of Allergy and Clinical Immunology·Mike A BerryChristopher E Brightling
Nov 18, 2004·Immunological Reviews·Marsha Wills-Karp
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·Neil W JohnstonMalcolm R Sears
Oct 12, 2005·American Journal of Respiratory and Critical Care Medicine·Stephen T Holgate
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Simon D MessageSebastian L Johnston
Nov 4, 2008·Emerging Infectious Diseases·Nino KhetsurianiDean D Erdman
Oct 24, 2009·Allergologia et immunopathologia·O LourençoL Taborda-Barata
Nov 26, 2009·The Journal of Allergy and Clinical Immunology·Scott P ComminsJohn W Steinke
Jun 2, 2010·The Journal of Allergy and Clinical Immunology·David J Jackson, Sebastian L Johnston
Dec 24, 2010·PloS One·Katrin PukelsheimMatthias Wjst
Apr 16, 2011·The Pediatric Infectious Disease Journal·Rainbow K Y MakTing F Leung

❮ Previous
Next ❯

Citations

Feb 25, 2020·Cellular Immunology·Ferdaus Mohd Altaf HossainSeong Kug Eo
Sep 11, 2020·The Lancet. Respiratory Medicine·Mariëlle W Pijnenburg, Louise Fleming
Nov 14, 2021·Acta Paediatrica·Manisha RamphulErol A Gaillard

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage

Software Mentioned

SPSS®
Bio
Plex [UNK]

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Journal of Allergy and Clinical Immunology
David B KantorJoel N Hirschhorn
The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Elida Duenas MezaMaría Del Pilar Delgado
American Journal of Clinical Pathology
Denise J McCullochColleen S Kraft
American Journal of Respiratory and Critical Care Medicine
H E FlemingH A Boushey
© 2022 Meta ULC. All rights reserved