Abstract
In children with asthma, the viral infection of airways is usually a main cause of acute asthma exacerbation and hospitalization. However, few studies on clinical and biomolecular characteristics of asthmatic children in this field have been done, especially in emergent countries. This study described the clinical and biological characteristics of asthmatic children who had acute asthma exacerbation and rhinovirus (RV) infection. Children under 15 years of age hospitalized for acute asthma exacerbation were included. They underwent clinical examination and peripheral blood analyses for the cytokine profile. The severity of acute asthma exacerbation was evaluated by Pediatric Asthma Score (PAS). Healthy children under 15 years of age were also invited in this study. One hundred fifteen asthmatic children were included in this study. There were 18.2% of mild PAS, 37.4% of moderate PAS, and 44.4% of severe PSA. Among them, 63/115 (54.8%) asthmatic children had positive RV infection (RV+). The percentages of asthmatic children with RV+ had increased polymorphonuclear leucocytes were significantly higher than asthmatic children with RV-. There were no significant differences of the concentrations of non-Th2-related cytokines in asth...Continue Reading
References
Oct 1, 1994·American Journal of Respiratory and Critical Care Medicine·C WalkerB Villiger
Jun 1, 1997·American Journal of Respiratory and Critical Care Medicine·J E GernW W Busse
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·H Z ShiZ F Xie
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·H E FlemingH A Boushey
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·K GrünbergP J Sterk
Jul 31, 2001·Journal of Clinical Pathology·J C Renauld
Jun 28, 2003·Viral Immunology·Mutsuo Yamaya, Hidetada Sasaki
Nov 13, 2004·The Journal of Allergy and Clinical Immunology·Mike A BerryChristopher E Brightling
Nov 18, 2004·Immunological Reviews·Marsha Wills-Karp
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·Neil W JohnstonMalcolm R Sears
Oct 12, 2005·American Journal of Respiratory and Critical Care Medicine·Stephen T Holgate
Mar 19, 2008·The Journal of Pediatrics·Francine M DucharmeDavid McGillivray
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Simon D MessageSebastian L Johnston
Nov 4, 2008·Emerging Infectious Diseases·Nino KhetsurianiDean D Erdman
Oct 24, 2009·Allergologia et immunopathologia·O LourençoL Taborda-Barata
Nov 26, 2009·The Journal of Allergy and Clinical Immunology·Scott P ComminsJohn W Steinke
Jun 2, 2010·The Journal of Allergy and Clinical Immunology·David J Jackson, Sebastian L Johnston
Dec 24, 2010·PloS One·Katrin PukelsheimMatthias Wjst
Apr 16, 2011·The Pediatric Infectious Disease Journal·Rainbow K Y MakTing F Leung
Jul 14, 2017·The Journal of International Medical Research·Thuy Nguyen-Thi-DieuSy Duong-Quy
Citations
Feb 25, 2020·Cellular Immunology·Ferdaus Mohd Altaf HossainSeong Kug Eo
Sep 11, 2020·The Lancet. Respiratory Medicine·Mariëlle W Pijnenburg, Louise Fleming
Nov 14, 2021·Acta Paediatrica·Manisha RamphulErol A Gaillard