PMID: 6994834May 1, 1980

Study of cross reactions between group A streptococcal antigens and cardiac interstitial connective tissue fibroblasts of different species of mammals

Biulleten' eksperimental'noĭ biologii i meditsiny
E V KochetkovaE N Semenova

Abstract

It has been revealed by indirect immunofluorescence that sera of rabbits immunized with group A streptococcal non-type-specific antigens and F (ab')2 fragments of IgG obtained from these sera intensively react with fibroblasts of interstitial connective tissue (ICT) of the myocardium of humans and different mammalian species with the exception of rabbits. Negative or weak reactions with the same sera and F (ab')2 fragments were observed with fibroblasts of ICT of nonimmunized rabbits. Myocardial ICT of immunized animals showed bound immunoglobulins. This model can be used for making clear the reason for presence in sera of rheumatic patients circulating antibodies only to heterologous but not to homologous ICT of the myocardium regardless of the revealing bound immunoglobulins in the ICT of these patients.

References

Jun 1, 1978·Clinical Immunology and Immunopathology·Y MizoguchiT Umeda
Jan 1, 1976·Journal of Immunological Methods·L H Madsen, L S Rodkey

Citations

Jan 1, 1986·Biulleten' eksperimental'noĭ biologii i meditsiny·L V BeletskaiaE V Kochetkova
Jun 1, 1988·Biulleten' eksperimental'noĭ biologii i meditsiny·E I DrobyshevskaiaV Iu Sanina

Related Concepts

Antigens, Bacterial
Autoantibodies
Bos indicus
Cross Reactions
Fibroblasts
Immunofluorescence Assay
Cavia porcellus
Heart
Fab Immunoglobulins
Myocardium

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